Kinome-wide shRNA Screen Identifies the Receptor Tyrosine Kinase AXL as a Key Regulator for Mesenchymal Glioblastoma Stem-like Cells

Glioblastoma is a highly lethal cancer for which novel therapeutics are urgently needed. Two distinct subtypes of glioblastoma stem-like cells (GSCs) were recently identified: mesenchymal (MES) and proneural (PN). To identify mechanisms to target the more aggressive MES GSCs, we combined transcripto...

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Detalles Bibliográficos
Autores principales: Cheng, Peng, Phillips, Emma, Kim, Sung-Hak, Taylor, David, Hielscher, Thomas, Puccio, Laura, Hjelmeland, Anita B., Lichter, Peter, Nakano, Ichiro, Goidts, Violaine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4437464/
https://www.ncbi.nlm.nih.gov/pubmed/25921812
http://dx.doi.org/10.1016/j.stemcr.2015.03.005

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