Emergence of a Stage-Dependent Human Liver Disease Signature with Directed Differentiation of Alpha-1 Antitrypsin-Deficient iPS Cells

Induced pluripotent stem cells (iPSCs) provide an inexhaustible source of cells for modeling disease and testing drugs. Here we develop a bioinformatic approach to detect differences between the genomic programs of iPSCs derived from diseased versus normal human cohorts as they emerge during in vitr...

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Detalles Bibliográficos
Autores principales: Wilson, Andrew A., Ying, Lei, Liesa, Marc, Segeritz, Charis-Patricia, Mills, Jason A., Shen, Steven S., Jean, Jyhchang, Lonza, Geordie C., Liberti, Derek C., Lang, Alex H., Nazaire, Jean, Gower, Adam C., Müeller, Franz-Josef, Mehta, Pankaj, Ordóñez, Adriana, Lomas, David A., Vallier, Ludovic, Murphy, George J., Mostoslavsky, Gustavo, Spira, Avrum, Shirihai, Orian S., Ramirez, Maria I., Gadue, Paul, Kotton, Darrell N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4437473/
https://www.ncbi.nlm.nih.gov/pubmed/25843048
http://dx.doi.org/10.1016/j.stemcr.2015.02.021

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