Regulation of the microtubular cytoskeleton by Polycystin-1 favors focal adhesions turnover to modulate cell adhesion and migration

BACKGROUND: Polycystin-1 (PC-1) is a large plasma membrane receptor, encoded by the PKD1 gene, which is mutated in most cases of Autosomal Dominant Polycystic Kidney Disease (ADPKD). The disease is characterized by renal cysts. The precise function of PC-1 remains elusive, although several studies s...

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Detalles Bibliográficos
Autores principales: Castelli, Maddalena, De Pascalis, Chiara, Distefano, Gianfranco, Ducano, Nadia, Oldani, Amanda, Lanzetti, Letizia, Boletta, Alessandra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4437554/
https://www.ncbi.nlm.nih.gov/pubmed/25947155
http://dx.doi.org/10.1186/s12860-015-0059-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4437554/
https://www.ncbi.nlm.nih.gov/pubmed/25947155
http://dx.doi.org/10.1186/s12860-015-0059-3

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