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Positive Selection of Natural Poly-Reactive B Cells in the Periphery Occurs Independent of Heavy Chain Allelic Inclusion

Natural autoreactive B cells are important mediators of autoimmune diseases. Receptor editing is known to play an important role in both central and peripheral B cell tolerance. However, the role of allelic inclusion in the development of natural autoreactive B cells is not clear. Previously, we gen...

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Detalles Bibliográficos
Autores principales: Xing, Ying, Ji, Qiuhe, Lin, Ying, Fu, Meng, Gao, Jixin, Zhang, Ping, Hu, Xingbin, Feng, Lei, Liu, Yufeng, Han, Hua, Li, Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4437983/
https://www.ncbi.nlm.nih.gov/pubmed/25993514
http://dx.doi.org/10.1371/journal.pone.0125747