A Multiplexed Cell-Based Assay for the Identification of Modulators of Pre-Membrane Processing as a Target against Dengue Virus

The DenV pre-membrane protein (prM) is a crucial chaperone for the viral envelope protein, preventing premature fusion with vesicles during viral export. prM molecules in immature particles are cleaved by host proteases, leading to mature fusogenic virions. Blockade of prM cleavage would restrict fu...

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Detalles Bibliográficos
Autores principales: Stolp, Zachary D., Smurthwaite, Cameron A., Reed, Connor, Williams, Wesley, Dharmawan, Andre, Djaballah, Hakim, Wolkowicz, Roland
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2015
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4438100/
https://www.ncbi.nlm.nih.gov/pubmed/25724189
http://dx.doi.org/10.1177/1087057115571247

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4438100/
https://www.ncbi.nlm.nih.gov/pubmed/25724189
http://dx.doi.org/10.1177/1087057115571247

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