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Lipotoxic Stress Induces Pancreatic β-Cell Apoptosis through Modulation of Bcl-2 Proteins by the Ubiquitin-Proteasome System

Pancreatic β-cell loss induced by saturated free fatty acids (FFAs) is believed to contribute to type 2 diabetes. Previous studies have shown induction of endoplasmic reticulum (ER) stress, increased ubiquitinated proteins, and deregulation of the Bcl-2 family in the pancreas of type 2 diabetic pati...

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Detalles Bibliográficos
Autores principales:	Litwak, Sara A., Wali, Jibran A., Pappas, Evan G., Saadi, Hamdi, Stanley, William J., Varanasi, L. Chitra, Kay, Thomas W. H., Thomas, Helen E., Gurzov, Esteban N.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi Publishing Corporation 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4438180/ https://www.ncbi.nlm.nih.gov/pubmed/26064977 http://dx.doi.org/10.1155/2015/280615

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