An updated role of microRNA-124 in central nervous system disorders: a review

MicroRNA-124 (miR-124) is the most abundant miRNA in the brain. Biogenesis of miR-124 displays specific temporal and spatial profiles in various cell and tissue types and affects a broad spectrum of biological functions in the central nervous system (CNS). Recently, the link between dysregulation of...

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Detalles Bibliográficos
Autores principales: Sun, Yang, Luo, Zhu-Min, Guo, Xiu-Ming, Su, Ding-Feng, Liu, Xia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2015
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4438253/
https://www.ncbi.nlm.nih.gov/pubmed/26041995
http://dx.doi.org/10.3389/fncel.2015.00193
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author Sun, Yang
Luo, Zhu-Min
Guo, Xiu-Ming
Su, Ding-Feng
Liu, Xia
author_facet Sun, Yang
Luo, Zhu-Min
Guo, Xiu-Ming
Su, Ding-Feng
Liu, Xia
author_sort Sun, Yang
collection PubMed
description MicroRNA-124 (miR-124) is the most abundant miRNA in the brain. Biogenesis of miR-124 displays specific temporal and spatial profiles in various cell and tissue types and affects a broad spectrum of biological functions in the central nervous system (CNS). Recently, the link between dysregulation of miR-124 and CNS disorders, such as neurodegeneration, CNS stress, neuroimmune disorders, stroke, and brain tumors, has become evident. Here, we provide an overview of the specific molecular function of miR-124 in the CNS and a revealing insight for the therapeutic potential of miR-124 in the treatment of human CNS diseases.
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spelling pubmed-44382532015-06-03 An updated role of microRNA-124 in central nervous system disorders: a review Sun, Yang Luo, Zhu-Min Guo, Xiu-Ming Su, Ding-Feng Liu, Xia Front Cell Neurosci Neuroscience MicroRNA-124 (miR-124) is the most abundant miRNA in the brain. Biogenesis of miR-124 displays specific temporal and spatial profiles in various cell and tissue types and affects a broad spectrum of biological functions in the central nervous system (CNS). Recently, the link between dysregulation of miR-124 and CNS disorders, such as neurodegeneration, CNS stress, neuroimmune disorders, stroke, and brain tumors, has become evident. Here, we provide an overview of the specific molecular function of miR-124 in the CNS and a revealing insight for the therapeutic potential of miR-124 in the treatment of human CNS diseases. Frontiers Media S.A. 2015-05-20 /pmc/articles/PMC4438253/ /pubmed/26041995 http://dx.doi.org/10.3389/fncel.2015.00193 Text en Copyright © 2015 Sun, Luo, Guo, Su and Liu. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Sun, Yang
Luo, Zhu-Min
Guo, Xiu-Ming
Su, Ding-Feng
Liu, Xia
An updated role of microRNA-124 in central nervous system disorders: a review
title An updated role of microRNA-124 in central nervous system disorders: a review
title_full An updated role of microRNA-124 in central nervous system disorders: a review
title_fullStr An updated role of microRNA-124 in central nervous system disorders: a review
title_full_unstemmed An updated role of microRNA-124 in central nervous system disorders: a review
title_short An updated role of microRNA-124 in central nervous system disorders: a review
title_sort updated role of microrna-124 in central nervous system disorders: a review
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4438253/
https://www.ncbi.nlm.nih.gov/pubmed/26041995
http://dx.doi.org/10.3389/fncel.2015.00193
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