C-terminal threonines and serines play distinct roles in the desensitization of rhodopsin, a G protein-coupled receptor

Rod photoreceptors generate measurable responses to single-photon activation of individual molecules of the G protein-coupled receptor (GPCR), rhodopsin. Timely rhodopsin desensitization depends on phosphorylation and arrestin binding, which quenches G protein activation. Rhodopsin phosphorylation h...

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Detalles Bibliográficos
Autores principales: Azevedo, Anthony W, Doan, Thuy, Moaven, Hormoz, Sokal, Iza, Baameur, Faiza, Vishnivetskiy, Sergey A, Homan, Kristoff T, Tesmer, John JG, Gurevich, Vsevolod V, Chen, Jeannie, Rieke, Fred
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2015
Materias:
Biophysics and Structural Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4438306/
https://www.ncbi.nlm.nih.gov/pubmed/25910054
http://dx.doi.org/10.7554/eLife.05981

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