Recovery of renal function succeeding stem cell transplant: a case of C3 Glomerulonephiritis secondary to monoclonal gammopathy

Membranoproliferative glomerulonephritis (MPGN) and C3 glomerulonephritis (C3 GN) can be secondary to monoclonal gammopathy and multiple myeloma. MPGN Type 1 is caused by activation of the classical pathway by immune complex formation, and C3 GN results from abnormalities in the alternative pathway...

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Autores principales: Andersen, Camilla Aakjær, Marcussen, Niels, Gregersen, Jon Waarst
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2013
Materias:
Clinical Cases
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4438372/
https://www.ncbi.nlm.nih.gov/pubmed/26069834
http://dx.doi.org/10.1093/ckj/sft124
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author Andersen, Camilla Aakjær
Marcussen, Niels
Gregersen, Jon Waarst
author_facet Andersen, Camilla Aakjær
Marcussen, Niels
Gregersen, Jon Waarst
author_sort Andersen, Camilla Aakjær
collection PubMed
description Membranoproliferative glomerulonephritis (MPGN) and C3 glomerulonephritis (C3 GN) can be secondary to monoclonal gammopathy and multiple myeloma. MPGN Type 1 is caused by activation of the classical pathway by immune complex formation, and C3 GN results from abnormalities in the alternative pathway of complement. In previously reported cases of MPGN and C3 GN secondary to monoclonal gammopathy/multiple myeloma, renal outcome has been poor. Here, we present the first patient, to our knowledge, who showed full renal recovery and normalization of the complement system after chemotherapy and stem cell transplantation.
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spelling pubmed-44383722015-06-11 Recovery of renal function succeeding stem cell transplant: a case of C3 Glomerulonephiritis secondary to monoclonal gammopathy Andersen, Camilla Aakjær Marcussen, Niels Gregersen, Jon Waarst Clin Kidney J Clinical Cases Membranoproliferative glomerulonephritis (MPGN) and C3 glomerulonephritis (C3 GN) can be secondary to monoclonal gammopathy and multiple myeloma. MPGN Type 1 is caused by activation of the classical pathway by immune complex formation, and C3 GN results from abnormalities in the alternative pathway of complement. In previously reported cases of MPGN and C3 GN secondary to monoclonal gammopathy/multiple myeloma, renal outcome has been poor. Here, we present the first patient, to our knowledge, who showed full renal recovery and normalization of the complement system after chemotherapy and stem cell transplantation. Oxford University Press 2013-12 2013-11-04 /pmc/articles/PMC4438372/ /pubmed/26069834 http://dx.doi.org/10.1093/ckj/sft124 Text en © The Author 2013. Published by Oxford University Press on behalf of ERA-EDTA. All rights reserved. For permissions, please email: journals.permissions@oup.com. http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Clinical Cases
Andersen, Camilla Aakjær
Marcussen, Niels
Gregersen, Jon Waarst
Recovery of renal function succeeding stem cell transplant: a case of C3 Glomerulonephiritis secondary to monoclonal gammopathy
title Recovery of renal function succeeding stem cell transplant: a case of C3 Glomerulonephiritis secondary to monoclonal gammopathy
title_full Recovery of renal function succeeding stem cell transplant: a case of C3 Glomerulonephiritis secondary to monoclonal gammopathy
title_fullStr Recovery of renal function succeeding stem cell transplant: a case of C3 Glomerulonephiritis secondary to monoclonal gammopathy
title_full_unstemmed Recovery of renal function succeeding stem cell transplant: a case of C3 Glomerulonephiritis secondary to monoclonal gammopathy
title_short Recovery of renal function succeeding stem cell transplant: a case of C3 Glomerulonephiritis secondary to monoclonal gammopathy
title_sort recovery of renal function succeeding stem cell transplant: a case of c3 glomerulonephiritis secondary to monoclonal gammopathy
topic Clinical Cases
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4438372/
https://www.ncbi.nlm.nih.gov/pubmed/26069834
http://dx.doi.org/10.1093/ckj/sft124
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AT gregersenjonwaarst recoveryofrenalfunctionsucceedingstemcelltransplantacaseofc3glomerulonephiritissecondarytomonoclonalgammopathy

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