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SKF83959 Produces Antidepressant Effects in a Chronic Social Defeat Stress Model of Depression through BDNF-TrkB Pathway

BACKGROUND: SKF83959 stimulates the phospholipase Cβ/inositol phosphate 3 pathway, resulting in the activation of Ca(2+)/calmodulin-dependent kinase IIα, which affects the synthesis of brain-derived neurotrophic factor, a neurotrophic factor critical for the pathophysiology of depression. Previous r...

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Detalles Bibliográficos
Autores principales:	Jiang, Bo, Wang, Fang, Yang, Si, Fang, Peng, Deng, Zhi-Fang, Xiao, Jun-Li, Hu, Zhuang-Li, Chen, Jian-Guo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4438541/ https://www.ncbi.nlm.nih.gov/pubmed/25522427 http://dx.doi.org/10.1093/ijnp/pyu096

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