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Melatonin Attenuates Memory Impairment Induced by Klotho Gene Deficiency Via Interactive Signaling Between MT2 Receptor, ERK, and Nrf2-Related Antioxidant Potential

BACKGROUND: We demonstrated that oxidative stress plays a crucial role in cognitive impairment in klotho mutant mice, a genetic model of aging. Since down-regulation of melatonin due to aging is well documented, we used this genetic model to determine whether the antioxidant property of melatonin af...

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Detalles Bibliográficos
Autores principales:	Shin, Eun-Joo, Chung, Yoon Hee, Le, Hoang-Lan Thi, Jeong, Ji Hoon, Dang, Duy-Khanh, Nam, Yunsung, Wie, Myung Bok, Nah, Seung-Yeol, Nabeshima, Yo-Ichi, Nabeshima, Toshitaka, Kim, Hyoung-Chun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4438546/ https://www.ncbi.nlm.nih.gov/pubmed/25550330 http://dx.doi.org/10.1093/ijnp/pyu105

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