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Glycated albumin and the risk of micro- and macrovascular complications in subjects with Type 1 Diabetes
BACKGROUND: We investigated the relationship between the glycemic indices glycated albumin (GA) and glycated hemoglobin (HbA(1c)) and the progression of diabetic vascular complications [diabetic nephropathy (DN) and carotid artery atherosclerosis (CAA)] in subjects with type 1 diabetes (T1D). METHOD...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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BioMed Central
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4438622/ https://www.ncbi.nlm.nih.gov/pubmed/25975731 http://dx.doi.org/10.1186/s12933-015-0219-y |
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author | Yoon, Hye-jin Lee, Yong-ho Kim, So Ra Rim, Tyler Hyungtaek Lee, Eun Young Kang, Eun Seok Cha, Bong-Soo Lee, Hyun Chul Lee, Byung-Wan |
author_facet | Yoon, Hye-jin Lee, Yong-ho Kim, So Ra Rim, Tyler Hyungtaek Lee, Eun Young Kang, Eun Seok Cha, Bong-Soo Lee, Hyun Chul Lee, Byung-Wan |
author_sort | Yoon, Hye-jin |
collection | PubMed |
description | BACKGROUND: We investigated the relationship between the glycemic indices glycated albumin (GA) and glycated hemoglobin (HbA(1c)) and the progression of diabetic vascular complications [diabetic nephropathy (DN) and carotid artery atherosclerosis (CAA)] in subjects with type 1 diabetes (T1D). METHODS: A total of 154 participants with a median follow-up of 2.8 years were enrolled in this retrospective longitudinal study. We recruited T1D subjects who had regularly measured urine albumin-creatinine ratios and estimated glomerular filtration rates, as well as tested HbA(1c) and GA levels consecutively every 3 or 6 months. A subgroup of 54 subjects was measured repeated carotid intima-media thickness (IMT). RESULTS: We classified subjects into the DN progression (Group I; n = 30) with either deteriorated stages of chronic kidney disease (n = 18) or albuminuria progression (n = 17), and the non-progression (Group II; n = 124). In multiple logistic regression analyses, baseline albuminuria (odds ratio [OR] = 2.64, 95 % confidence interval [CI] = 1.03–6.74), mean GA levels (OR = 2.03, 95 % CI = 1.27–3.26) were significantly associated with progression of DN. However, there was no association with mean HbA(1c) (OR = 0.98, 95 % CI = 0.62–1.54). In a subgroup analysis for follow-up measurements of carotid IMT, age was independently associated with the presence of plaque and the mean IMT. However glycemic indices were not significantly associated with CAA. CONCLUSIONS: Mean GA levels were more closely associated with DN progression than mean HbA(1c) in subjects with T1D. However, they were not associated with the CAA. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s12933-015-0219-y) contains supplementary material, which is available to authorized users. |
format | Online Article Text |
id | pubmed-4438622 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-44386222015-05-21 Glycated albumin and the risk of micro- and macrovascular complications in subjects with Type 1 Diabetes Yoon, Hye-jin Lee, Yong-ho Kim, So Ra Rim, Tyler Hyungtaek Lee, Eun Young Kang, Eun Seok Cha, Bong-Soo Lee, Hyun Chul Lee, Byung-Wan Cardiovasc Diabetol Original Investigation BACKGROUND: We investigated the relationship between the glycemic indices glycated albumin (GA) and glycated hemoglobin (HbA(1c)) and the progression of diabetic vascular complications [diabetic nephropathy (DN) and carotid artery atherosclerosis (CAA)] in subjects with type 1 diabetes (T1D). METHODS: A total of 154 participants with a median follow-up of 2.8 years were enrolled in this retrospective longitudinal study. We recruited T1D subjects who had regularly measured urine albumin-creatinine ratios and estimated glomerular filtration rates, as well as tested HbA(1c) and GA levels consecutively every 3 or 6 months. A subgroup of 54 subjects was measured repeated carotid intima-media thickness (IMT). RESULTS: We classified subjects into the DN progression (Group I; n = 30) with either deteriorated stages of chronic kidney disease (n = 18) or albuminuria progression (n = 17), and the non-progression (Group II; n = 124). In multiple logistic regression analyses, baseline albuminuria (odds ratio [OR] = 2.64, 95 % confidence interval [CI] = 1.03–6.74), mean GA levels (OR = 2.03, 95 % CI = 1.27–3.26) were significantly associated with progression of DN. However, there was no association with mean HbA(1c) (OR = 0.98, 95 % CI = 0.62–1.54). In a subgroup analysis for follow-up measurements of carotid IMT, age was independently associated with the presence of plaque and the mean IMT. However glycemic indices were not significantly associated with CAA. CONCLUSIONS: Mean GA levels were more closely associated with DN progression than mean HbA(1c) in subjects with T1D. However, they were not associated with the CAA. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s12933-015-0219-y) contains supplementary material, which is available to authorized users. BioMed Central 2015-05-15 /pmc/articles/PMC4438622/ /pubmed/25975731 http://dx.doi.org/10.1186/s12933-015-0219-y Text en © Yoon et al.; licensee BioMed Central. 2015 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Original Investigation Yoon, Hye-jin Lee, Yong-ho Kim, So Ra Rim, Tyler Hyungtaek Lee, Eun Young Kang, Eun Seok Cha, Bong-Soo Lee, Hyun Chul Lee, Byung-Wan Glycated albumin and the risk of micro- and macrovascular complications in subjects with Type 1 Diabetes |
title | Glycated albumin and the risk of micro- and macrovascular complications in subjects with Type 1 Diabetes |
title_full | Glycated albumin and the risk of micro- and macrovascular complications in subjects with Type 1 Diabetes |
title_fullStr | Glycated albumin and the risk of micro- and macrovascular complications in subjects with Type 1 Diabetes |
title_full_unstemmed | Glycated albumin and the risk of micro- and macrovascular complications in subjects with Type 1 Diabetes |
title_short | Glycated albumin and the risk of micro- and macrovascular complications in subjects with Type 1 Diabetes |
title_sort | glycated albumin and the risk of micro- and macrovascular complications in subjects with type 1 diabetes |
topic | Original Investigation |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4438622/ https://www.ncbi.nlm.nih.gov/pubmed/25975731 http://dx.doi.org/10.1186/s12933-015-0219-y |
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