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Fibroblast growth factor-2 regulates human cardiac myofibroblast-mediated extracellular matrix remodeling
BACKGROUND: Tissue fibrosis and chamber remodeling is a hallmark of the failing heart and the final common pathway for heart failure of diverse etiologies. Sustained elevation of pro-fibrotic cytokine transforming growth factor-beta1 (TGFβ1) induces cardiac myofibroblast-mediated fibrosis and progre...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4438633/ https://www.ncbi.nlm.nih.gov/pubmed/25948488 http://dx.doi.org/10.1186/s12967-015-0510-4 |