Cargando…

Effect of Vitamin D, Calcium and Multiple Micronutrients Supplementation on Lipid Profile in Pre-menopausal Bangladeshi Garment Factory Workers with Hypovitaminosis D

Elevated total cholesterol and low-density lipoprotein cholesterol in sera are both well-known risk factors of coronary heart disease. Adequate vitamin D status is important for optimal function of many organs and tissues of our body. There is continuing controversy about the effect of adequate vita...

Descripción completa

Detalles Bibliográficos
Autores principales: Islam, Md. Zahirul, Shamim, Abu Ahmed, Ahmed, Abu, Akhtaruzzaman, Mohammad, Kärkkäinen, Merja, Lamberg-Allardt, Christel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Centre for Diarrhoeal Disease Research, Bangladesh 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4438699/
https://www.ncbi.nlm.nih.gov/pubmed/25895202
_version_ 1782372383919702016
author Islam, Md. Zahirul
Shamim, Abu Ahmed
Ahmed, Abu
Akhtaruzzaman, Mohammad
Kärkkäinen, Merja
Lamberg-Allardt, Christel
author_facet Islam, Md. Zahirul
Shamim, Abu Ahmed
Ahmed, Abu
Akhtaruzzaman, Mohammad
Kärkkäinen, Merja
Lamberg-Allardt, Christel
author_sort Islam, Md. Zahirul
collection PubMed
description Elevated total cholesterol and low-density lipoprotein cholesterol in sera are both well-known risk factors of coronary heart disease. Adequate vitamin D status is important for optimal function of many organs and tissues of our body. There is continuing controversy about the effect of adequate vitamin D consumption on serum lipids and lipoproteins. The present study assessed the effect of vitamin D, calcium and multiple micronutrients supplementation on the lipid profile in Bangladeshi young female garment factory workers who have hypovitaminosis D. This placebo-controlled intervention trial conducted over a period of one year randomly assigned a total of 200 apparently healthy subjects aged 16-36 years to 4 groups. The subjects received daily supplements of 400 IU of vitamin D (VD group) or 400 IU of vitamin D+600 mg of calcium lactate (VD-Ca group), or multiple micronutrients with 400 IU of vitamin-D+600 mg of calcium lactate (MMN-VD-Ca group), or the group consuming placebo (PL group). Serum concentrations of lipid and lipoprotein, 25-hydroxyvitamin D (25OHD) and intact parathyroid hormone (iPTH) were measured at baseline and after one year of follow-up. No significant changes in the serum levels of total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), LDL-C/HDL-C ratio were observed in the supplemented groups compared to the placebo group. Supplementation had a positive effect (p<0.05) on very low-density lipoprotein cholesterol (VLDL-C) and triacylglycerol (TAG). A negative correlation between changes in serum iPTH and HDL-C was observed, which indicated that subjects with the greatest decline in S-iPTH had the greatest increase in HDL-C. The results suggest that consumption of adequate vitamin D with calcium or MMN for one-year may have no impact on serum lipid profile in the subjects studied. Longer-term clinical trials with different doses of supplemental vitamin D are warranted in evaluating the effect of intervention.
format Online
Article
Text
id pubmed-4438699
institution National Center for Biotechnology Information
language English
publishDate 2014
publisher International Centre for Diarrhoeal Disease Research, Bangladesh
record_format MEDLINE/PubMed
spelling pubmed-44386992015-05-20 Effect of Vitamin D, Calcium and Multiple Micronutrients Supplementation on Lipid Profile in Pre-menopausal Bangladeshi Garment Factory Workers with Hypovitaminosis D Islam, Md. Zahirul Shamim, Abu Ahmed Ahmed, Abu Akhtaruzzaman, Mohammad Kärkkäinen, Merja Lamberg-Allardt, Christel J Health Popul Nutr Original Papers Elevated total cholesterol and low-density lipoprotein cholesterol in sera are both well-known risk factors of coronary heart disease. Adequate vitamin D status is important for optimal function of many organs and tissues of our body. There is continuing controversy about the effect of adequate vitamin D consumption on serum lipids and lipoproteins. The present study assessed the effect of vitamin D, calcium and multiple micronutrients supplementation on the lipid profile in Bangladeshi young female garment factory workers who have hypovitaminosis D. This placebo-controlled intervention trial conducted over a period of one year randomly assigned a total of 200 apparently healthy subjects aged 16-36 years to 4 groups. The subjects received daily supplements of 400 IU of vitamin D (VD group) or 400 IU of vitamin D+600 mg of calcium lactate (VD-Ca group), or multiple micronutrients with 400 IU of vitamin-D+600 mg of calcium lactate (MMN-VD-Ca group), or the group consuming placebo (PL group). Serum concentrations of lipid and lipoprotein, 25-hydroxyvitamin D (25OHD) and intact parathyroid hormone (iPTH) were measured at baseline and after one year of follow-up. No significant changes in the serum levels of total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), LDL-C/HDL-C ratio were observed in the supplemented groups compared to the placebo group. Supplementation had a positive effect (p<0.05) on very low-density lipoprotein cholesterol (VLDL-C) and triacylglycerol (TAG). A negative correlation between changes in serum iPTH and HDL-C was observed, which indicated that subjects with the greatest decline in S-iPTH had the greatest increase in HDL-C. The results suggest that consumption of adequate vitamin D with calcium or MMN for one-year may have no impact on serum lipid profile in the subjects studied. Longer-term clinical trials with different doses of supplemental vitamin D are warranted in evaluating the effect of intervention. International Centre for Diarrhoeal Disease Research, Bangladesh 2014-12 /pmc/articles/PMC4438699/ /pubmed/25895202 Text en © INTERNATIONAL CENTRE FOR DIARRHOEAL DISEASE RESEARCH, BANGLADESH http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Papers
Islam, Md. Zahirul
Shamim, Abu Ahmed
Ahmed, Abu
Akhtaruzzaman, Mohammad
Kärkkäinen, Merja
Lamberg-Allardt, Christel
Effect of Vitamin D, Calcium and Multiple Micronutrients Supplementation on Lipid Profile in Pre-menopausal Bangladeshi Garment Factory Workers with Hypovitaminosis D
title Effect of Vitamin D, Calcium and Multiple Micronutrients Supplementation on Lipid Profile in Pre-menopausal Bangladeshi Garment Factory Workers with Hypovitaminosis D
title_full Effect of Vitamin D, Calcium and Multiple Micronutrients Supplementation on Lipid Profile in Pre-menopausal Bangladeshi Garment Factory Workers with Hypovitaminosis D
title_fullStr Effect of Vitamin D, Calcium and Multiple Micronutrients Supplementation on Lipid Profile in Pre-menopausal Bangladeshi Garment Factory Workers with Hypovitaminosis D
title_full_unstemmed Effect of Vitamin D, Calcium and Multiple Micronutrients Supplementation on Lipid Profile in Pre-menopausal Bangladeshi Garment Factory Workers with Hypovitaminosis D
title_short Effect of Vitamin D, Calcium and Multiple Micronutrients Supplementation on Lipid Profile in Pre-menopausal Bangladeshi Garment Factory Workers with Hypovitaminosis D
title_sort effect of vitamin d, calcium and multiple micronutrients supplementation on lipid profile in pre-menopausal bangladeshi garment factory workers with hypovitaminosis d
topic Original Papers
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4438699/
https://www.ncbi.nlm.nih.gov/pubmed/25895202
work_keys_str_mv AT islammdzahirul effectofvitamindcalciumandmultiplemicronutrientssupplementationonlipidprofileinpremenopausalbangladeshigarmentfactoryworkerswithhypovitaminosisd
AT shamimabuahmed effectofvitamindcalciumandmultiplemicronutrientssupplementationonlipidprofileinpremenopausalbangladeshigarmentfactoryworkerswithhypovitaminosisd
AT ahmedabu effectofvitamindcalciumandmultiplemicronutrientssupplementationonlipidprofileinpremenopausalbangladeshigarmentfactoryworkerswithhypovitaminosisd
AT akhtaruzzamanmohammad effectofvitamindcalciumandmultiplemicronutrientssupplementationonlipidprofileinpremenopausalbangladeshigarmentfactoryworkerswithhypovitaminosisd
AT karkkainenmerja effectofvitamindcalciumandmultiplemicronutrientssupplementationonlipidprofileinpremenopausalbangladeshigarmentfactoryworkerswithhypovitaminosisd
AT lambergallardtchristel effectofvitamindcalciumandmultiplemicronutrientssupplementationonlipidprofileinpremenopausalbangladeshigarmentfactoryworkerswithhypovitaminosisd