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Crystal structure of ethyl 2-cyano-3-[(1-eth­oxy­ethyl­idene)amino]-5-(3-meth­oxy­phen­yl)-7-methyl-5H-1,3-thia­zolo[3,2-a]pyrimidine-6-carboxyl­ate

In the title compound, C(22)H(24)N(4)O(4)S, the central pyrimidine ring adopts a sofa conformation with the ring-junction N atom displaced by 0.2358 (6) Å from the mean plane of the remaining ring atoms. The 3-meth­oxy­phenyl ring, at the chiral C atom opposite the other N atom, is positioned axiall...

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Detalles Bibliográficos
Autores principales: Krishnamurthy, M. S., Begum, Noor Shahina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Union of Crystallography 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4438835/
https://www.ncbi.nlm.nih.gov/pubmed/26029443
http://dx.doi.org/10.1107/S2056989015005241
Descripción
Sumario:In the title compound, C(22)H(24)N(4)O(4)S, the central pyrimidine ring adopts a sofa conformation with the ring-junction N atom displaced by 0.2358 (6) Å from the mean plane of the remaining ring atoms. The 3-meth­oxy­phenyl ring, at the chiral C atom opposite the other N atom, is positioned axially and is inclined to the thia­zolo­pyrimidine ring with a dihedral angle of 83.88 (7)°. The thia­zole ring is essentially planar (r.m.s. deviation = 0.0034 Å). In the crystal, pairs of weak C—H⋯O hydrogen bonds link mol­ecules related by twofold rotation axes to form R (2) (2)(8) rings, which in turn are linked by weak C—H⋯N inter­actions, forming ribbons along [-110]. In addition, π–π stacking inter­actions [centroid—centroid distance = 3.5744 (15) Å] connect the ribbons, forming slabs lying parallel to (001).