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Three Huntington’s Disease Specific Mutation-Carrying Human Embryonic Stem Cell Lines Have Stable Number of CAG Repeats upon In Vitro Differentiation into Cardiomyocytes

Huntington disease (HD; OMIM 143100), a progressive neurodegenerative disorder, is caused by an expanded trinucleotide CAG (polyQ) motif in the HTT gene. Cardiovascular symptoms, often present in early stage HD patients, are, in general, ascribed to dysautonomia. However, cardio-specific expression...

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Detalles Bibliográficos
Autores principales:	Jacquet, Laureen, Neueder, Andreas, Földes, Gabor, Karagiannis, Panagiotis, Hobbs, Carl, Jolinon, Nelly, Mioulane, Maxime, Sakai, Takao, Harding, Sian E., Ilic, Dusko
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4438866/ https://www.ncbi.nlm.nih.gov/pubmed/25993131 http://dx.doi.org/10.1371/journal.pone.0126860

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