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Lipid metabolism disorders and bone dysfunction-interrelated and mutually regulated (Review)

The association between lipid and bone metabolism has become an increasing focus of interest in recent years, and accumulating evidence has shown that atherosclerosis (AS) and osteoporosis (OP), a disorder of bone metabolism, frequently co-exist. Fat and bone are known to share a common progenitor c...

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Detalles Bibliográficos
Autores principales: TIAN, LI, YU, XIJIE
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4438959/
https://www.ncbi.nlm.nih.gov/pubmed/25760577
http://dx.doi.org/10.3892/mmr.2015.3472
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author TIAN, LI
YU, XIJIE
author_facet TIAN, LI
YU, XIJIE
author_sort TIAN, LI
collection PubMed
description The association between lipid and bone metabolism has become an increasing focus of interest in recent years, and accumulating evidence has shown that atherosclerosis (AS) and osteoporosis (OP), a disorder of bone metabolism, frequently co-exist. Fat and bone are known to share a common progenitor cell: Multipotent mesenchymal stem cells (MSC) in the bone marrow (BM), which are able to differentiate into various cell phenotypes, including osteoblasts, adipocytes and chondrocytes. Laboratory-based and clinical trials have shown that increasing adipocytes are accompanied by a decrease in bone mineral density (BMD) and bone mass. Statins, lipid-lowering drugs used to treat hyperlipidemia, also provide benefit in the treatment of OP. There is thus evidence that the metabolism of lipids is correlated with that of bone, and that the two are mutually regulated. The present review primarily focuses on the potential association between lipid metabolism disturbance and OP, based on biological metabolism, pathophysiological processes, results from clinical and experimental animal studies, processes involved in the differentiation of adipocytes and osteoblasts, as well as pharmacological treatments of these diseases.
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spelling pubmed-44389592015-06-05 Lipid metabolism disorders and bone dysfunction-interrelated and mutually regulated (Review) TIAN, LI YU, XIJIE Mol Med Rep Articles The association between lipid and bone metabolism has become an increasing focus of interest in recent years, and accumulating evidence has shown that atherosclerosis (AS) and osteoporosis (OP), a disorder of bone metabolism, frequently co-exist. Fat and bone are known to share a common progenitor cell: Multipotent mesenchymal stem cells (MSC) in the bone marrow (BM), which are able to differentiate into various cell phenotypes, including osteoblasts, adipocytes and chondrocytes. Laboratory-based and clinical trials have shown that increasing adipocytes are accompanied by a decrease in bone mineral density (BMD) and bone mass. Statins, lipid-lowering drugs used to treat hyperlipidemia, also provide benefit in the treatment of OP. There is thus evidence that the metabolism of lipids is correlated with that of bone, and that the two are mutually regulated. The present review primarily focuses on the potential association between lipid metabolism disturbance and OP, based on biological metabolism, pathophysiological processes, results from clinical and experimental animal studies, processes involved in the differentiation of adipocytes and osteoblasts, as well as pharmacological treatments of these diseases. D.A. Spandidos 2015-07 2015-03-11 /pmc/articles/PMC4438959/ /pubmed/25760577 http://dx.doi.org/10.3892/mmr.2015.3472 Text en Copyright © 2015, Spandidos Publications http://creativecommons.org/licenses/by/3.0 This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
spellingShingle Articles
TIAN, LI
YU, XIJIE
Lipid metabolism disorders and bone dysfunction-interrelated and mutually regulated (Review)
title Lipid metabolism disorders and bone dysfunction-interrelated and mutually regulated (Review)
title_full Lipid metabolism disorders and bone dysfunction-interrelated and mutually regulated (Review)
title_fullStr Lipid metabolism disorders and bone dysfunction-interrelated and mutually regulated (Review)
title_full_unstemmed Lipid metabolism disorders and bone dysfunction-interrelated and mutually regulated (Review)
title_short Lipid metabolism disorders and bone dysfunction-interrelated and mutually regulated (Review)
title_sort lipid metabolism disorders and bone dysfunction-interrelated and mutually regulated (review)
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4438959/
https://www.ncbi.nlm.nih.gov/pubmed/25760577
http://dx.doi.org/10.3892/mmr.2015.3472
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