Model-Free RNA Sequence and Structure Alignment Informed by SHAPE Probing Reveals a Conserved Alternate Secondary Structure for 16S rRNA

Discovery and characterization of functional RNA structures remains challenging due to deficiencies in de novo secondary structure modeling. Here we describe a dynamic programming approach for model-free sequence comparison that incorporates high-throughput chemical probing data. Based on SHAPE prob...

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Detalles Bibliográficos
Autores principales: Lavender, Christopher A., Lorenz, Ronny, Zhang, Ge, Tamayo, Rita, Hofacker, Ivo L., Weeks, Kevin M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4438973/
https://www.ncbi.nlm.nih.gov/pubmed/25992778
http://dx.doi.org/10.1371/journal.pcbi.1004126

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