Cargando…

The Longitudinal Transcriptomic Response of the Substantia Nigra to Intrastriatal 6-Hydroxydopamine Reveals Significant Upregulation of Regeneration-Associated Genes

We hypothesized that the study of gene expression at 1, 2, 4, 6 and 16 weeks in the substantia nigra (SN) after intrastriatal 6-OHDA in the Sprague-Dawley rat (rattus norvegicus) would identify cellular responses during the degenerative process that could be axoprotective. Specifically, we hypothesi...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kanaan, Nicholas M., Collier, Timothy J., Cole-Strauss, Allyson, Grabinski, Tessa, Mattingly, Zachary R., Winn, Mary E., Steece-Collier, Kathy, Sortwell, Caryl E., Manfredsson, Fredric P., Lipton, Jack W.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4439078/ https://www.ncbi.nlm.nih.gov/pubmed/25992874 http://dx.doi.org/10.1371/journal.pone.0127768

Ejemplares similares

High-Frequency Stimulation of the Rat Entopeduncular Nucleus Does Not Provide Functional or Morphological Neuroprotection from 6-Hydroxydopamine
por: Fischer, D. Luke, et al.
Publicado: (2015)

Genetic silencing of striatal CaV1.3 prevents and ameliorates levodopa dyskinesia
por: Steece‐Collier, Kathy, et al.
Publicado: (2019)

Intrastriatally Infused Exogenous CDNF Is Endocytosed and Retrogradely Transported to Substantia Nigra
por: Mätlik, Kert, et al.
Publicado: (2017)

Subthalamic Nucleus Deep Brain Stimulation Does Not Modify the Functional Deficits or Axonopathy Induced by Nigrostriatal α-Synuclein Overexpression
por: Fischer, D. Luke, et al.
Publicado: (2017)

Downregulation of striatal Ca(V)1.3 inhibits the escalation of levodopa-induced dyskinesia in male and female parkinsonian rats of advanced age
por: Caulfield, Margaret E., et al.
Publicado: (2023)

Is Alpha-Synuclein Loss-of-Function a Contributor to Parkinsonian Pathology? Evidence from Non-human Primates
por: Collier, Timothy J., et al.
Publicado: (2016)

Cell therapy for Parkinson's disease: Why it doesn't work every time
por: Collier, Timothy J., et al.
Publicado: (2019)

Impact of age and vector construct on striatal and nigral transgene expression
por: Polinski, Nicole K, et al.
Publicado: (2016)

The BDNF Val66Met polymorphism (rs6265) enhances dopamine neuron graft efficacy and side-effect liability in rs6265 knock-in rats
por: Mercado, Natosha M., et al.
Publicado: (2020)

6‐Hydroxydopamine lesion and levodopa treatment modify the effect of buspirone in the substantia nigra pars reticulata
por: Vegas‐Suárez, Sergio, et al.
Publicado: (2020)

A Method for Combining RNAscope In Situ Hybridization with Immunohistochemistry in Thick Free-Floating Brain Sections and Primary Neuronal Cultures
por: Grabinski, Tessa M., et al.
Publicado: (2015)

Transient transfection of human CDNF gene reduces the 6-hydroxydopamine-induced neuroinflammation in the rat substantia nigra
por: Nadella, Rasajna, et al.
Publicado: (2014)

Paeonol Protection Against Intrastriatal 6-Hydroxydopamine Rat Model of Parkinson’s Disease
por: Ghalami, Jamileh, et al.
Publicado: (2021)

Soemmerring and the Substantia Nigra
por: Faull, R. L. M, et al.
Publicado: (1968)

Sonic Hedgehog Controls the Phenotypic Fate and Therapeutic Efficacy of Grafted Neural Precursor Cells in a Model of Nigrostriatal Neurodegeneration
por: Madhavan, Lalitha, et al.
Publicado: (2015)

Antioxidant Effect of Alpha-Lipoic Acid in 6-Hydroxydopamine Unilateral Intrastriatal Injected Rats
por: Andreeva-Gateva, Pavlina, et al.
Publicado: (2020)

Striatal Afferent BDNF Is Disrupted by Synucleinopathy and Partially Restored by STN DBS
por: Miller, Kathryn M., et al.
Publicado: (2021)

Biochemical Changes Induced by Embryonic Substantia Nigra Transplanted to the Striatum of Parkinsonian Monkeys
por: Elsworth, J. D., et al.
Publicado: (1992)

Longitudinal assessment of motor function following the unilateral intrastriatal 6-hydroxydopamine lesion model in mice
por: Sun, Xiuping, et al.
Publicado: (2022)

Silencing Alpha Synuclein in Mature Nigral Neurons Results in Rapid Neuroinflammation and Subsequent Toxicity
por: Benskey, Matthew J., et al.
Publicado: (2018)

Treatment with a Substance P Receptor Antagonist Is Neuroprotective in the Intrastriatal 6-Hydroxydopamine Model of Early Parkinson's Disease
por: Thornton, Emma, et al.
Publicado: (2012)

Unilateral Intrastriatal 6-Hydroxydopamine Lesion in Mice: A Closer Look into Non-Motor Phenotype and Glial Response
por: Mendes-Pinheiro, Bárbara, et al.
Publicado: (2021)

Mapping Chemical Elements and Iron Oxidation States in the Substantia Nigra of 6-Hydroxydopamine Lesioned Rats Using Correlative Immunohistochemistry With Proton and Synchrotron Micro-Analysis
por: Carmona, Asuncion, et al.
Publicado: (2019)

The history of the research of iron in parkinsonian substantia nigra
por: Friedman, Andrzej, et al.
Publicado: (2012)

Isolated substantia nigra involvement in brainstem demyelination
por: Mahale, Rohan R., et al.
Publicado: (2015)

Nicotine impact on rat substantia nigra compacta
por: Elgayar, Sanaa A M, et al.
Publicado: (2021)

Regulation of dopamine neurotransmission from serotonergic neurons by ectopic expression of the dopamine D2 autoreceptor blocks levodopa-induced dyskinesia
por: Sellnow, Rhyomi C., et al.
Publicado: (2019)

Enhanced training protects memory against amnesia produced by concurrent inactivation of amygdala and striatum, amygdala and substantia nigra, or striatum and substantia nigra
por: Salado-Castillo, Rigoberto, et al.
Publicado: (2011)

Proteome analysis of human substantia nigra in Parkinson's disease
por: Werner, Cornelius J, et al.
Publicado: (2008)

Bidirectional Modulation of Substantia Nigra Activity by Motivational State
por: Rossi, Mark A., et al.
Publicado: (2013)

Operant Self-Stimulation of Dopamine Neurons in the Substantia Nigra
por: Rossi, Mark A., et al.
Publicado: (2013)

Epstein-Barr virus encephalitis with substantia nigra involvement
por: Çelik, Tamer, et al.
Publicado: (2015)

Mesencephalic origin of the rostral Substantia nigra pars reticulata
por: Madrigal, M. Pilar, et al.
Publicado: (2015)

Glucocerebrosidase Deficiency in Substantia Nigra of Parkinson Disease Brains
por: Gegg, Matthew E, et al.
Publicado: (2012)

Degeneration of the Substantia Nigra Following Ipsilateral Striatal Infarction
por: Ohtomo, Gaku, et al.
Publicado: (2017)

Proliferation of Inhibitory Input to the Substantia Nigra in Experimental Parkinsonism
por: Faynveitz, Anna, et al.
Publicado: (2019)

α-Synuclein antisense oligonucleotides as a disease-modifying therapy for Parkinson’s disease
por: Cole, Tracy A., et al.
Publicado: (2021)

Complement activation in the Parkinson's disease substantia nigra: an immunocytochemical study
por: Loeffler, David A, et al.
Publicado: (2006)

Parcellation of the human substantia nigra based on anatomical connectivity to the striatum()
por: Chowdhury, Rumana, et al.
Publicado: (2013)

Tollip, an early regulator of the acute inflammatory response in the substantia nigra
por: Humbert-Claude, Marie, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_strtkbt63bj4i8i8fo6vblnt45