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Impact of the H275Y and I223V Mutations in the Neuraminidase of the 2009 Pandemic Influenza Virus In Vitro and Evaluating Experimental Reproducibility

The 2009 pandemic H1N1 (H1N1pdm09) influenza virus is naturally susceptible to neuraminidase (NA) inhibitors, but mutations in the NA protein can cause oseltamivir resistance. The H275Y and I223V amino acid substitutions in the NA of the H1N1pdm09 influenza strain have been separately observed in pa...

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Detalles Bibliográficos
Autores principales:	Paradis, Eric G., Pinilla, Lady Tatiana, Holder, Benjamin P., Abed, Yacine, Boivin, Guy, Beauchemin, Catherine A.A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4439092/ https://www.ncbi.nlm.nih.gov/pubmed/25992792 http://dx.doi.org/10.1371/journal.pone.0126115

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