Cargando…

The Myelin and Lymphocyte Protein MAL Is Required for Binding and Activity of Clostridium perfringens ε-Toxin

Clostridium perfringens ε-toxin (ETX) is a potent pore-forming toxin responsible for a central nervous system (CNS) disease in ruminant animals with characteristics of blood-brain barrier (BBB) dysfunction and white matter injury. ETX has been proposed as a potential causative agent for Multiple Scl...

Descripción completa

Detalles Bibliográficos
Autores principales:	Rumah, Kareem Rashid, Ma, Yinghua, Linden, Jennifer R., Oo, Myat Lin, Anrather, Josef, Schaeren-Wiemers, Nicole, Alonso, Miguel A., Fischetti, Vincent A., McClain, Mark S., Vartanian, Timothy
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4439126/ https://www.ncbi.nlm.nih.gov/pubmed/25993478 http://dx.doi.org/10.1371/journal.ppat.1004896

Ejemplares similares

Clostridium perfringens Epsilon Toxin Causes Selective Death of Mature Oligodendrocytes and Central Nervous System Demyelination
por: Linden, Jennifer R., et al.
Publicado: (2015)

Isolation of Clostridium perfringens Type B in an Individual at First Clinical Presentation of Multiple Sclerosis Provides Clues for Environmental Triggers of the Disease
por: Rumah, Kareem Rashid, et al.
Publicado: (2013)

Clostridium perfringens Epsilon Toxin Binds to and Kills Primary Human Lymphocytes
por: Shetty, Samantha V., et al.
Publicado: (2023)

Oral Multiple Sclerosis Drugs Inhibit the In vitro Growth of Epsilon Toxin Producing Gut Bacterium, Clostridium perfringens
por: Rumah, Kareem R., et al.
Publicado: (2017)

Gene-Trap Mutagenesis Identifies Mammalian Genes Contributing to Intoxication by Clostridium perfringens ε-Toxin
por: Ivie, Susan E., et al.
Publicado: (2011)

Identification of Small Molecule Inhibitors of Clostridium perfringens ε-Toxin Cytotoxicity Using a Cell-Based High-Throughput Screen
por: Lewis, Michelle, et al.
Publicado: (2010)

Clostridium perfringens epsilon toxin induces blood brain barrier permeability via caveolae-dependent transcytosis and requires expression of MAL
por: Linden, Jennifer R., et al.
Publicado: (2019)

Oligomerization of Clostridium perfringens Epsilon Toxin Is Dependent upon Caveolins 1 and 2
por: Fennessey, Christine M., et al.
Publicado: (2012)

Clostridium perfringens Epsilon Toxin Compromises the Blood-Brain Barrier in a Humanized Zebrafish Model
por: Adler, Drew, et al.
Publicado: (2019)

Clostridium perfringens epsilon toxin binds to erythrocyte MAL receptors and triggers phosphatidylserine exposure
por: Geng, Zhijun, et al.
Publicado: (2020)

Epsilon toxin–producing Clostridium perfringens colonize the multiple sclerosis gut microbiome overcoming CNS immune privilege
por: Ma, Yinghua, et al.
Publicado: (2023)

Systematic evaluation of membrane-camouflaged nanoparticles in neutralizing Clostridium perfringens ε-toxin
por: Xu, Jinglin, et al.
Publicado: (2023)

PLGA Nanoparticle-Based Dissolving Microneedle Vaccine of Clostridium perfringens ε Toxin
por: Wan, Wei, et al.
Publicado: (2023)

MAL Overexpression Leads to Disturbed Expression of Genes That Influence Cytoskeletal Organization and Differentiation of Schwann Cells
por: Schmid, Daniela, et al.
Publicado: (2014)

Clostridium perfringens epsilon toxin vaccine candidate lacking toxicity to cells expressing myelin and lymphocyte protein
por: Morcrette, Helen, et al.
Publicado: (2019)

Regulation of Toxin Production in Clostridium perfringens
por: Ohtani, Kaori, et al.
Publicado: (2016)

Acute Effect of Pore-Forming Clostridium perfringens ε-Toxin on Compound Action Potentials of Optic Nerve of Mouse
por: Cases, Mercè, et al.
Publicado: (2017)

A Novel Panel of Rabbit Monoclonal Antibodies and Their Diverse Applications Including Inhibition of Clostridium perfringens Epsilon Toxin Oligomerization
por: Linden, Jennifer R., et al.
Publicado: (2018)

Clostridium perfringens Iota-Toxin: Structure and Function
por: Sakurai, Jun, et al.
Publicado: (2009)

Perfringolysin O: The Underrated Clostridium perfringens Toxin?
por: Verherstraeten, Stefanie, et al.
Publicado: (2015)

Recent Insights into Clostridium perfringens Beta-Toxin
por: Nagahama, Masahiro, et al.
Publicado: (2015)

Effect of Clostridium perfringens β-Toxin on Platelets
por: Thiel, Anne, et al.
Publicado: (2017)

The pore structure of Clostridium perfringens epsilon toxin
por: Savva, Christos G., et al.
Publicado: (2019)

A role for the Clostridium perfringens β2 toxin in bovine enterotoxaemia?
por: Manteca, C, et al.
Publicado: (2002)

Expression of α- and ε-toxin genes in Clostridium perfringens type D vaccine strain in contact with the Caco-2 cell line
por: Forouzan, A. R., et al.
Publicado: (2022)

MAL/VIP17, a New Player in the Regulation of NKCC2 in the Kidney
por: Carmosino, Monica, et al.
Publicado: (2010)

Cellular Entry of Clostridium perfringens Iota-Toxin and Clostridium botulinum C2 Toxin
por: Takehara, Masaya, et al.
Publicado: (2017)

Clostridium Perfringens Toxins Involved in Mammalian Veterinary Diseases
por: Uzal, F. A., et al.
Publicado: (2010)

Membrane-Binding Mechanism of Clostridium perfringens Alpha-Toxin
por: Oda, Masataka, et al.
Publicado: (2015)

Targeted Mass Spectrometry Analysis of Clostridium perfringens Toxins
por: Duracova, Miloslava, et al.
Publicado: (2019)

Is Clostridium perfringens epsilon toxin associated with multiple sclerosis?
por: Titball, Richard W, et al.
Publicado: (2023)

The raft-associated protein MAL is required for maintenance of proper axon–glia interactions in the central nervous system
por: Schaeren-Wiemers, Nicole, et al.
Publicado: (2004)

Pathogenicity and virulence of Clostridium perfringens
por: Mehdizadeh Gohari, Iman, et al.
Publicado: (2021)

Structural Insights into Clostridium perfringens Delta Toxin Pore Formation
por: Huyet, Jessica, et al.
Publicado: (2013)

Clostridium perfringens Delta-Toxin Induces Rapid Cell Necrosis
por: Seike, Soshi, et al.
Publicado: (2016)

Diversity of Clostridium perfringens toxin-genotypes from dairy farms
por: Fohler, Svenja, et al.
Publicado: (2016)

Targeting oncogenic Ras by the Clostridium perfringens toxin TpeL
por: Schorch, Björn, et al.
Publicado: (2018)

Mechanisms of Action and Cell Death Associated with Clostridium perfringens Toxins
por: Navarro, Mauricio A., et al.
Publicado: (2018)

Evidence of Clostridium perfringens epsilon toxin associated with multiple sclerosis
por: Wagley, Sariqa, et al.
Publicado: (2018)

Clostridium perfringens Delta-Toxin Damages the Mouse Small Intestine
por: Seike, Soshi, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_q0l96mp89fogico476ncmcaqc1