The ubiquitin-modifying enzyme A20 restricts the ubiquitination of RIPK3 and protects cells from necroptosis

A20 is an anti-inflammatory protein linked to multiple human diseases, however the mechanisms by which A20 prevents inflammatory disease are incompletely defined. We now find that A20 deficient T cells and fibroblasts are susceptible to caspase independent and RIPK3 dependent necroptosis. Global RIP...

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Detalles Bibliográficos
Autores principales: Onizawa, Michio, Oshima, Shigeru, Schulze-Topphoff, Ulf, Oses-Prieto, Juan A, Lu, Timothy, Tavares, Rita, Prodhomme, Thomas, Duong, Bao, Whang, Michael I., Advincula, Rommel, Agelidis, Alex, Barrera, Julio, Wu, Hao, Burlingame, Alma, Malynn, Barbara A., Zamvil, Scott S., Ma, Averil
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4439357/
https://www.ncbi.nlm.nih.gov/pubmed/25939025
http://dx.doi.org/10.1038/ni.3172

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