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Receptor-binding domain-based subunit vaccines against MERS-CoV
Development of effective vaccines, in particular, subunit-based vaccines, against emerging Middle East respiratory syndrome (MERS) caused by the MERS coronavirus (MERS-CoV) will provide the safest means of preventing the continuous spread of MERS in humans and camels. This review briefly describes t...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier B.V.
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4439384/ https://www.ncbi.nlm.nih.gov/pubmed/25445336 http://dx.doi.org/10.1016/j.virusres.2014.11.013 |
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author | Zhang, Naru Tang, Jian Lu, Lu Jiang, Shibo Du, Lanying |
author_facet | Zhang, Naru Tang, Jian Lu, Lu Jiang, Shibo Du, Lanying |
author_sort | Zhang, Naru |
collection | PubMed |
description | Development of effective vaccines, in particular, subunit-based vaccines, against emerging Middle East respiratory syndrome (MERS) caused by the MERS coronavirus (MERS-CoV) will provide the safest means of preventing the continuous spread of MERS in humans and camels. This review briefly describes the structure of the MERS-CoV spike (S) protein and its receptor-binding domain (RBD), discusses the current status of MERS vaccine development and illustrates the strategies used to develop RBD-based subunit vaccines against MERS. It also summarizes currently available animal models for MERS-CoV and proposes a future direction for MERS vaccines. Taken together, this review will assist researchers working to develop effective and safe subunit vaccines against MERS-CoV and any other emerging coronaviruses that might cause future pandemics. |
format | Online Article Text |
id | pubmed-4439384 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Elsevier B.V. |
record_format | MEDLINE/PubMed |
spelling | pubmed-44393842016-04-16 Receptor-binding domain-based subunit vaccines against MERS-CoV Zhang, Naru Tang, Jian Lu, Lu Jiang, Shibo Du, Lanying Virus Res Article Development of effective vaccines, in particular, subunit-based vaccines, against emerging Middle East respiratory syndrome (MERS) caused by the MERS coronavirus (MERS-CoV) will provide the safest means of preventing the continuous spread of MERS in humans and camels. This review briefly describes the structure of the MERS-CoV spike (S) protein and its receptor-binding domain (RBD), discusses the current status of MERS vaccine development and illustrates the strategies used to develop RBD-based subunit vaccines against MERS. It also summarizes currently available animal models for MERS-CoV and proposes a future direction for MERS vaccines. Taken together, this review will assist researchers working to develop effective and safe subunit vaccines against MERS-CoV and any other emerging coronaviruses that might cause future pandemics. Elsevier B.V. 2015-04-16 2014-11-20 /pmc/articles/PMC4439384/ /pubmed/25445336 http://dx.doi.org/10.1016/j.virusres.2014.11.013 Text en Copyright © 2014 Elsevier B.V. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active. |
spellingShingle | Article Zhang, Naru Tang, Jian Lu, Lu Jiang, Shibo Du, Lanying Receptor-binding domain-based subunit vaccines against MERS-CoV |
title | Receptor-binding domain-based subunit vaccines against MERS-CoV |
title_full | Receptor-binding domain-based subunit vaccines against MERS-CoV |
title_fullStr | Receptor-binding domain-based subunit vaccines against MERS-CoV |
title_full_unstemmed | Receptor-binding domain-based subunit vaccines against MERS-CoV |
title_short | Receptor-binding domain-based subunit vaccines against MERS-CoV |
title_sort | receptor-binding domain-based subunit vaccines against mers-cov |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4439384/ https://www.ncbi.nlm.nih.gov/pubmed/25445336 http://dx.doi.org/10.1016/j.virusres.2014.11.013 |
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