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Receptor-binding domain-based subunit vaccines against MERS-CoV

Development of effective vaccines, in particular, subunit-based vaccines, against emerging Middle East respiratory syndrome (MERS) caused by the MERS coronavirus (MERS-CoV) will provide the safest means of preventing the continuous spread of MERS in humans and camels. This review briefly describes t...

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Detalles Bibliográficos
Autores principales: Zhang, Naru, Tang, Jian, Lu, Lu, Jiang, Shibo, Du, Lanying
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier B.V. 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4439384/
https://www.ncbi.nlm.nih.gov/pubmed/25445336
http://dx.doi.org/10.1016/j.virusres.2014.11.013
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author Zhang, Naru
Tang, Jian
Lu, Lu
Jiang, Shibo
Du, Lanying
author_facet Zhang, Naru
Tang, Jian
Lu, Lu
Jiang, Shibo
Du, Lanying
author_sort Zhang, Naru
collection PubMed
description Development of effective vaccines, in particular, subunit-based vaccines, against emerging Middle East respiratory syndrome (MERS) caused by the MERS coronavirus (MERS-CoV) will provide the safest means of preventing the continuous spread of MERS in humans and camels. This review briefly describes the structure of the MERS-CoV spike (S) protein and its receptor-binding domain (RBD), discusses the current status of MERS vaccine development and illustrates the strategies used to develop RBD-based subunit vaccines against MERS. It also summarizes currently available animal models for MERS-CoV and proposes a future direction for MERS vaccines. Taken together, this review will assist researchers working to develop effective and safe subunit vaccines against MERS-CoV and any other emerging coronaviruses that might cause future pandemics.
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spelling pubmed-44393842016-04-16 Receptor-binding domain-based subunit vaccines against MERS-CoV Zhang, Naru Tang, Jian Lu, Lu Jiang, Shibo Du, Lanying Virus Res Article Development of effective vaccines, in particular, subunit-based vaccines, against emerging Middle East respiratory syndrome (MERS) caused by the MERS coronavirus (MERS-CoV) will provide the safest means of preventing the continuous spread of MERS in humans and camels. This review briefly describes the structure of the MERS-CoV spike (S) protein and its receptor-binding domain (RBD), discusses the current status of MERS vaccine development and illustrates the strategies used to develop RBD-based subunit vaccines against MERS. It also summarizes currently available animal models for MERS-CoV and proposes a future direction for MERS vaccines. Taken together, this review will assist researchers working to develop effective and safe subunit vaccines against MERS-CoV and any other emerging coronaviruses that might cause future pandemics. Elsevier B.V. 2015-04-16 2014-11-20 /pmc/articles/PMC4439384/ /pubmed/25445336 http://dx.doi.org/10.1016/j.virusres.2014.11.013 Text en Copyright © 2014 Elsevier B.V. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Zhang, Naru
Tang, Jian
Lu, Lu
Jiang, Shibo
Du, Lanying
Receptor-binding domain-based subunit vaccines against MERS-CoV
title Receptor-binding domain-based subunit vaccines against MERS-CoV
title_full Receptor-binding domain-based subunit vaccines against MERS-CoV
title_fullStr Receptor-binding domain-based subunit vaccines against MERS-CoV
title_full_unstemmed Receptor-binding domain-based subunit vaccines against MERS-CoV
title_short Receptor-binding domain-based subunit vaccines against MERS-CoV
title_sort receptor-binding domain-based subunit vaccines against mers-cov
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4439384/
https://www.ncbi.nlm.nih.gov/pubmed/25445336
http://dx.doi.org/10.1016/j.virusres.2014.11.013
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