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Nanolipoparticles-mediated MDR1 siRNA delivery reduces doxorubicin resistance in breast cancer cells and silences MDR1 expression in xenograft model of human breast cancer

OBJECTIVE(S): P-glycoprotein (P-gp) is an efflux protein, the overexpression of which has been associated with multidrug resistance in various cancers. Although siRNA delivery to reverse P-gp expression may be promising for sensitizing of tumor cells to cytotoxic drugs, the therapeutic use of siRNA...

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Detalles Bibliográficos
Autores principales:	Nourbakhsh, Mahnaz, Jaafari, Mahmoud Reza, Lage, Hermann, Abnous, Khalil, mosaffa, Fatemeh, Badiee, Ali, Behravan, Javad
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Mashhad University of Medical Sciences 2015
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4439454/ https://www.ncbi.nlm.nih.gov/pubmed/26019802

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