Cargando…

Nanolipoparticles-mediated MDR1 siRNA delivery reduces doxorubicin resistance in breast cancer cells and silences MDR1 expression in xenograft model of human breast cancer

OBJECTIVE(S): P-glycoprotein (P-gp) is an efflux protein, the overexpression of which has been associated with multidrug resistance in various cancers. Although siRNA delivery to reverse P-gp expression may be promising for sensitizing of tumor cells to cytotoxic drugs, the therapeutic use of siRNA...

Descripción completa

Detalles Bibliográficos
Autores principales:	Nourbakhsh, Mahnaz, Jaafari, Mahmoud Reza, Lage, Hermann, Abnous, Khalil, mosaffa, Fatemeh, Badiee, Ali, Behravan, Javad
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Mashhad University of Medical Sciences 2015
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4439454/ https://www.ncbi.nlm.nih.gov/pubmed/26019802

Ejemplares similares

Development of RNA aptamers as molecular probes for HER2(+) breast cancer study using cell-SELEX
por: Moosavian, Seyedeh Alia, et al.
Publicado: (2015)

miR‐495 sensitizes MDR cancer cells to the combination of doxorubicin and taxol by inhibiting MDR1 expression
por: Zou, Zhenyou, et al.
Publicado: (2017)

Comparative proteomics study of proteins involved in induction of higher rates of cell death in mitoxantrone-resistant breast cancer cells MCF-7/MX exposed to TNF-α
por: Norouzi, Saeed, et al.
Publicado: (2020)

Identification of genes and pathways associated with MDR in MCF-7/MDR breast cancer cells by RNA-seq analysis
por: Yang, Minlan, et al.
Publicado: (2018)

Ecdysteroids Sensitize MDR and Non-MDR Cancer Cell Lines to Doxorubicin, Paclitaxel, and Vincristine but Tend to Protect Them from Cisplatin
por: Martins, Ana, et al.
Publicado: (2015)

Cetuximab-Modified Human Serum Albumin Nanoparticles Co-Loaded with Doxorubicin and MDR1 siRNA for the Treatment of Drug-Resistant Breast Tumors
por: Yang, Xin, et al.
Publicado: (2021)

Inhibition of Akt phosphorylation attenuates resistance to TNF-α cytotoxic effects in MCF-7 cells, but not in their doxorubicin resistant derivatives
por: Ghandadi, Morteza, et al.
Publicado: (2016)

Inhibition of MDR1 expression with altritol-modified siRNAs
por: Fisher, Michael, et al.
Publicado: (2007)

Conjugated nanoliposome with the HER2/neu-derived peptide GP2 as an effective vaccine against breast cancer in mice xenograft model
por: Razazan, Atefeh, et al.
Publicado: (2017)

The siRNA targeted to mdr1b and mdr1a mRNAs in vivo sensitizes murine lymphosarcoma to chemotherapy
por: Patutina, Olga A, et al.
Publicado: (2010)

Interaction of WBP2 with ERα increases doxorubicin resistance of breast cancer cells by modulating MDR1 transcription
por: Chen, Shuai, et al.
Publicado: (2018)

Salinomycin enhances doxorubicin-induced cytotoxicity in multidrug resistant MCF-7/MDR human breast cancer cells via decreased efflux of doxorubicin
por: KIM, KWANG-YOUN, et al.
Publicado: (2015)

Codelivery of doxorubicin and MDR1-siRNA by mesoporous silica nanoparticles-polymerpolyethylenimine to improve oral squamous carcinoma treatment
por: Wang, Dandan, et al.
Publicado: (2017)

Celecoxib Up Regulates the Expression of Drug Efflux Transporter ABCG2 in Breast Cancer Cell Lines
por: Kalalinia, Fatemeh, et al.
Publicado: (2014)

Codelivery of Doxorubicin and MDR1-siRNA by Mesoporous Silica Nanoparticles-Polymerpolyethylenimine to Improve Oral Squamous Carcinoma Treatment [Corrigendum]
Publicado: (2021)

Relationship between the expression of cyclooxygenase 2 and MDR1/P-glycoprotein in invasive breast cancers and their prognostic significance
por: Surowiak, Pawel, et al.
Publicado: (2005)

Cholesterol-Containing Nuclease-Resistant siRNA Accumulates in Tumors in a Carrier-free Mode and Silences MDR1 Gene
por: Chernikov, Ivan V., et al.
Publicado: (2017)

MDR1 Inhibition Reverses Doxorubicin-Resistance in Six Doxorubicin-Resistant Canine Prostate and Bladder Cancer Cell Lines
por: Packeiser, Eva-Maria, et al.
Publicado: (2023)

‘Z(S)-MDR-TB' versus ‘Z(R)-MDR-TB': improving treatment of MDR-TB by identifying pyrazinamide susceptibility
por: Zhang, Ying, et al.
Publicado: (2012)

Epoxylathyrane Derivatives as MDR-Selective Compounds for Disabling Multidrug Resistance in Cancer
por: Reis, Mariana Alves, et al.
Publicado: (2020)

MRP1 but Not MDR1 Is Associated with Response to Neoadjuvant Chemotherapy in Breast Cancer Patients
por: Taheri, Mohsen, et al.
Publicado: (2013)

VE-Albumin Core-Shell Nanoparticles for Paclitaxel Delivery to Treat MDR Breast Cancer
por: Tang, Bo, et al.
Publicado: (2018)

Advances with metal oxide-based nanoparticles as MDR metastatic breast cancer therapeutics and diagnostics
por: Subhan, Md Abdus
Publicado: (2022)

CD44 Contributes to the Regulation of MDR1 Protein and Doxorubicin Chemoresistance in Osteosarcoma
por: Gerardo-Ramírez, Monserrat, et al.
Publicado: (2022)

MDR & XDR Tuberculosis
por: Kumar, Prahlad
Publicado: (2017)

MDR Tuberculosis Treatment
por: Espinosa-Pereiro, Juan, et al.
Publicado: (2022)

Multifunctional nanoparticles co-loaded with Adriamycin and MDR-targeting siRNAs for treatment of chemotherapy-resistant esophageal cancer
por: Zhang, Xiangyang, et al.
Publicado: (2022)

Multidrug resistance (mdr) genes in human cancer.
por: Nooter, K., et al.
Publicado: (1991)

Why has MDR-TB prevalence increased in Iran?
por: Heidary, Mohsen, et al.
Publicado: (2016)

MMP1 expression is activated by Slug and enhances multi-drug resistance (MDR) in breast cancer
por: Shen, Ching-Ju, et al.
Publicado: (2017)

Comparison of characteristics and mortality in multidrug resistant (MDR) and non-MDR tuberculosis patients in China
por: Sun, Yanni, et al.
Publicado: (2015)

The effect of varying multidrug-resistence (MDR) definitions on rates of MDR gram-negative rods
por: Wolfensberger, Aline, et al.
Publicado: (2019)

Nobiletin and its derivatives overcome multidrug resistance (MDR) in cancer: total synthesis and discovery of potent MDR reversal agents
por: Feng, Senling, et al.
Publicado: (2020)

Combination of polythyleneimine regulating autophagy prodrug and Mdr1 siRNA for tumor multidrug resistance
por: Wang, Changduo, et al.
Publicado: (2022)

Sinomenine Sensitizes Multidrug-Resistant Colon Cancer Cells (Caco-2) to Doxorubicin by Downregulation of MDR-1 Expression
por: Liu, Zhen, et al.
Publicado: (2014)

LncRNA H19 is a major mediator of doxorubicin chemoresistance in breast cancer cells through a cullin4A-MDR1 pathway
por: Zhu, Qiong-Ni, et al.
Publicado: (2017)

Pluronics and MDR Reversal: An Update
por: Alakhova, Daria Y., et al.
Publicado: (2014)

MDR TB Transmission, Singapore
por: Chee, Cynthia B.E., et al.
Publicado: (2013)

Raltegravir does not revert efflux activity of MDR1-P-glycoprotein in human MDR cells
por: Dupuis, Maria Luisa, et al.
Publicado: (2013)

Convergence of virulence and MDR in a single plasmid vector in MDR Klebsiella pneumoniae ST15
por: Lam, Margaret M C, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_qmnbbdqs2gsmeicnhriq33c1et