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Treatment of a Prader-Willi Patient with Recurrent Catatonia
Prader-Willi is a genetic disorder characterized by neonatal hypotonia, hyperphagia, short stature, hypogonadism, and mental delay. This disorder can result from multiple mechanisms, most commonly a deletion of paternal chromosome 15, leaving a single maternally derived chromosome 15. Individuals wh...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4439498/ https://www.ncbi.nlm.nih.gov/pubmed/26064753 http://dx.doi.org/10.1155/2015/697428 |
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author | Poser, Hana M. Trutia, Alexandru E. |
author_facet | Poser, Hana M. Trutia, Alexandru E. |
author_sort | Poser, Hana M. |
collection | PubMed |
description | Prader-Willi is a genetic disorder characterized by neonatal hypotonia, hyperphagia, short stature, hypogonadism, and mental delay. This disorder can result from multiple mechanisms, most commonly a deletion of paternal chromosome 15, leaving a single maternally derived chromosome 15. Individuals who have a maternal uniparental disomy of chromosome 15 have a higher risk for developing psychosis compared to other forms of Prader-Willi. The following report details the treatment course of a 24-year-old female with Prader-Willi and recurrent catatonia. The patient initially had a positive lorazepam challenge test but subsequently failed treatment with benzodiazepines. She then received eight electroconvulsive therapy (ECT) treatments after which she showed improvement from initial catatonic state. However, the resolution in her symptoms did not follow a linear course but would show periods of improvement followed by a return of catatonic features. This case provides an example of the complexity of treatment of a patient with a genetic disorder and recurrent catatonia. |
format | Online Article Text |
id | pubmed-4439498 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-44394982015-06-10 Treatment of a Prader-Willi Patient with Recurrent Catatonia Poser, Hana M. Trutia, Alexandru E. Case Rep Psychiatry Case Report Prader-Willi is a genetic disorder characterized by neonatal hypotonia, hyperphagia, short stature, hypogonadism, and mental delay. This disorder can result from multiple mechanisms, most commonly a deletion of paternal chromosome 15, leaving a single maternally derived chromosome 15. Individuals who have a maternal uniparental disomy of chromosome 15 have a higher risk for developing psychosis compared to other forms of Prader-Willi. The following report details the treatment course of a 24-year-old female with Prader-Willi and recurrent catatonia. The patient initially had a positive lorazepam challenge test but subsequently failed treatment with benzodiazepines. She then received eight electroconvulsive therapy (ECT) treatments after which she showed improvement from initial catatonic state. However, the resolution in her symptoms did not follow a linear course but would show periods of improvement followed by a return of catatonic features. This case provides an example of the complexity of treatment of a patient with a genetic disorder and recurrent catatonia. Hindawi Publishing Corporation 2015 2015-05-07 /pmc/articles/PMC4439498/ /pubmed/26064753 http://dx.doi.org/10.1155/2015/697428 Text en Copyright © 2015 H. M. Poser and A. E. Trutia. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Case Report Poser, Hana M. Trutia, Alexandru E. Treatment of a Prader-Willi Patient with Recurrent Catatonia |
title | Treatment of a Prader-Willi Patient with Recurrent Catatonia |
title_full | Treatment of a Prader-Willi Patient with Recurrent Catatonia |
title_fullStr | Treatment of a Prader-Willi Patient with Recurrent Catatonia |
title_full_unstemmed | Treatment of a Prader-Willi Patient with Recurrent Catatonia |
title_short | Treatment of a Prader-Willi Patient with Recurrent Catatonia |
title_sort | treatment of a prader-willi patient with recurrent catatonia |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4439498/ https://www.ncbi.nlm.nih.gov/pubmed/26064753 http://dx.doi.org/10.1155/2015/697428 |
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