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Human seroprevalence indicating hantavirus infections in tropical rainforests of Côte d’Ivoire and Democratic Republic of Congo

Hantaviruses are members of the Bunyaviridae family carried by small mammals and causing human hemorrhagic fevers worldwide. In Western Africa, where a variety of hemorrhagic fever viruses occurs, indigenous hantaviruses have been molecularly found in animal reservoirs such as rodents, shrews, and b...

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Autores principales: Witkowski, Peter T., Leendertz, Siv A. J., Auste, Brita, Akoua-Koffi, Chantal, Schubert, Grit, Klempa, Boris, Muyembe-Tamfum, Jean-Jacques, Karhemere, Stomy, Leendertz, Fabian H., Krüger, Detlev H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4439549/
https://www.ncbi.nlm.nih.gov/pubmed/26052326
http://dx.doi.org/10.3389/fmicb.2015.00518
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author Witkowski, Peter T.
Leendertz, Siv A. J.
Auste, Brita
Akoua-Koffi, Chantal
Schubert, Grit
Klempa, Boris
Muyembe-Tamfum, Jean-Jacques
Karhemere, Stomy
Leendertz, Fabian H.
Krüger, Detlev H.
author_facet Witkowski, Peter T.
Leendertz, Siv A. J.
Auste, Brita
Akoua-Koffi, Chantal
Schubert, Grit
Klempa, Boris
Muyembe-Tamfum, Jean-Jacques
Karhemere, Stomy
Leendertz, Fabian H.
Krüger, Detlev H.
author_sort Witkowski, Peter T.
collection PubMed
description Hantaviruses are members of the Bunyaviridae family carried by small mammals and causing human hemorrhagic fevers worldwide. In Western Africa, where a variety of hemorrhagic fever viruses occurs, indigenous hantaviruses have been molecularly found in animal reservoirs such as rodents, shrews, and bats since 2006. To investigate the human contact to hantaviruses carried by these hosts and to assess the public health relevance of hantaviruses for humans living in the tropical rainforest regions of Western and Central Africa, we performed a cross-sectional seroprevalence study in the region of Taï National Park in Côte d’Ivoire and the Bandundu region near the Salonga National Park in the Democratic Republic (DR) of Congo. Serum samples were initially screened with enzyme-linked immunosorbent assays using nucleoproteins of several hantaviruses as diagnostic antigens. Positive results were confirmed by Western blotting and immunofluorescence testing. Seroprevalence rates of 3.9% (27/687) and 2.4% (7/295), respectively, were found in the investigated regions in Côte d’Ivoire and the DR Congo. In Côte d’Ivoire, this value was significantly higher than the seroprevalence rates previously reported from the neighboring country Guinea as well as from South Africa. Our study indicates an exposure of humans to hantaviruses in West and Central African tropical rainforest areas. In order to pinpoint the possible existence and frequency of clinical disease caused by hantaviruses in this region of the world, systematic investigations of patients with fever and renal or respiratory symptoms are required.
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spelling pubmed-44395492015-06-05 Human seroprevalence indicating hantavirus infections in tropical rainforests of Côte d’Ivoire and Democratic Republic of Congo Witkowski, Peter T. Leendertz, Siv A. J. Auste, Brita Akoua-Koffi, Chantal Schubert, Grit Klempa, Boris Muyembe-Tamfum, Jean-Jacques Karhemere, Stomy Leendertz, Fabian H. Krüger, Detlev H. Front Microbiol Microbiology Hantaviruses are members of the Bunyaviridae family carried by small mammals and causing human hemorrhagic fevers worldwide. In Western Africa, where a variety of hemorrhagic fever viruses occurs, indigenous hantaviruses have been molecularly found in animal reservoirs such as rodents, shrews, and bats since 2006. To investigate the human contact to hantaviruses carried by these hosts and to assess the public health relevance of hantaviruses for humans living in the tropical rainforest regions of Western and Central Africa, we performed a cross-sectional seroprevalence study in the region of Taï National Park in Côte d’Ivoire and the Bandundu region near the Salonga National Park in the Democratic Republic (DR) of Congo. Serum samples were initially screened with enzyme-linked immunosorbent assays using nucleoproteins of several hantaviruses as diagnostic antigens. Positive results were confirmed by Western blotting and immunofluorescence testing. Seroprevalence rates of 3.9% (27/687) and 2.4% (7/295), respectively, were found in the investigated regions in Côte d’Ivoire and the DR Congo. In Côte d’Ivoire, this value was significantly higher than the seroprevalence rates previously reported from the neighboring country Guinea as well as from South Africa. Our study indicates an exposure of humans to hantaviruses in West and Central African tropical rainforest areas. In order to pinpoint the possible existence and frequency of clinical disease caused by hantaviruses in this region of the world, systematic investigations of patients with fever and renal or respiratory symptoms are required. Frontiers Media S.A. 2015-05-21 /pmc/articles/PMC4439549/ /pubmed/26052326 http://dx.doi.org/10.3389/fmicb.2015.00518 Text en Copyright © 2015 Witkowski, Leendertz, Auste, Akoua-Koffi, Schubert, Klempa, Muyembe-Tamfum, Karhemere, Leendertz and Krüger. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Microbiology
Witkowski, Peter T.
Leendertz, Siv A. J.
Auste, Brita
Akoua-Koffi, Chantal
Schubert, Grit
Klempa, Boris
Muyembe-Tamfum, Jean-Jacques
Karhemere, Stomy
Leendertz, Fabian H.
Krüger, Detlev H.
Human seroprevalence indicating hantavirus infections in tropical rainforests of Côte d’Ivoire and Democratic Republic of Congo
title Human seroprevalence indicating hantavirus infections in tropical rainforests of Côte d’Ivoire and Democratic Republic of Congo
title_full Human seroprevalence indicating hantavirus infections in tropical rainforests of Côte d’Ivoire and Democratic Republic of Congo
title_fullStr Human seroprevalence indicating hantavirus infections in tropical rainforests of Côte d’Ivoire and Democratic Republic of Congo
title_full_unstemmed Human seroprevalence indicating hantavirus infections in tropical rainforests of Côte d’Ivoire and Democratic Republic of Congo
title_short Human seroprevalence indicating hantavirus infections in tropical rainforests of Côte d’Ivoire and Democratic Republic of Congo
title_sort human seroprevalence indicating hantavirus infections in tropical rainforests of côte d’ivoire and democratic republic of congo
topic Microbiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4439549/
https://www.ncbi.nlm.nih.gov/pubmed/26052326
http://dx.doi.org/10.3389/fmicb.2015.00518
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