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Anterior cingulate cortex mediates the relationship between O3PUFAs and executive functions in APOE e4 carriers
Introduction: Although diet has a substantial influence on the aging brain, the relationship between biomarkers of diet and aspects of brain health remains unclear. This study examines the neural mechanisms that mediate the relationship between omega-3 polyunsaturated fatty acids (O3PUFAs) and execu...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2015
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4439554/ https://www.ncbi.nlm.nih.gov/pubmed/26052283 http://dx.doi.org/10.3389/fnagi.2015.00087 |
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author | Zamroziewicz, Marta K. Paul, Erick J. Rubin, Rachael D. Barbey, Aron K. |
author_facet | Zamroziewicz, Marta K. Paul, Erick J. Rubin, Rachael D. Barbey, Aron K. |
author_sort | Zamroziewicz, Marta K. |
collection | PubMed |
description | Introduction: Although diet has a substantial influence on the aging brain, the relationship between biomarkers of diet and aspects of brain health remains unclear. This study examines the neural mechanisms that mediate the relationship between omega-3 polyunsaturated fatty acids (O3PUFAs) and executive functions in at-risk (APOE e4 carriers), cognitively intact older adults. We hypothesized that higher levels of O3PUFAs are associated with better performance in a particular component of the executive functions, namely cognitive flexibility, and that this relationship is mediated by gray matter volume of a specific region thought to be important for cognitive flexibility, the anterior cingulate cortex. Methods: We examined 40 cognitively intact adults between the ages of 65 and 75 with the APOE e4 polymorphism to investigate the relationship between biomarkers of O3PUFAs, tests of cognitive flexibility (measured by the Delis-Kaplan Executive Function System Trail Making Test), and gray matter volume within regions of the prefrontal cortex (PFC). Results: A mediation analysis revealed that gray matter volume within the left rostral anterior cingulate cortex partially mediates the relationship between O3PUFA biomarkers and cognitive flexibility. Conclusion: These results suggest that the anterior cingulate cortex acts as a mediator of the relationship between O3PUFAs and cognitive flexibility in cognitively intact adults thought to be at risk for cognitive decline. Through their link to executive functions and neuronal measures of PFC volume, O3PUFAs show potential as a nutritional therapy to prevent dysfunction in the aging brain. |
format | Online Article Text |
id | pubmed-4439554 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-44395542015-06-05 Anterior cingulate cortex mediates the relationship between O3PUFAs and executive functions in APOE e4 carriers Zamroziewicz, Marta K. Paul, Erick J. Rubin, Rachael D. Barbey, Aron K. Front Aging Neurosci Neuroscience Introduction: Although diet has a substantial influence on the aging brain, the relationship between biomarkers of diet and aspects of brain health remains unclear. This study examines the neural mechanisms that mediate the relationship between omega-3 polyunsaturated fatty acids (O3PUFAs) and executive functions in at-risk (APOE e4 carriers), cognitively intact older adults. We hypothesized that higher levels of O3PUFAs are associated with better performance in a particular component of the executive functions, namely cognitive flexibility, and that this relationship is mediated by gray matter volume of a specific region thought to be important for cognitive flexibility, the anterior cingulate cortex. Methods: We examined 40 cognitively intact adults between the ages of 65 and 75 with the APOE e4 polymorphism to investigate the relationship between biomarkers of O3PUFAs, tests of cognitive flexibility (measured by the Delis-Kaplan Executive Function System Trail Making Test), and gray matter volume within regions of the prefrontal cortex (PFC). Results: A mediation analysis revealed that gray matter volume within the left rostral anterior cingulate cortex partially mediates the relationship between O3PUFA biomarkers and cognitive flexibility. Conclusion: These results suggest that the anterior cingulate cortex acts as a mediator of the relationship between O3PUFAs and cognitive flexibility in cognitively intact adults thought to be at risk for cognitive decline. Through their link to executive functions and neuronal measures of PFC volume, O3PUFAs show potential as a nutritional therapy to prevent dysfunction in the aging brain. Frontiers Media S.A. 2015-05-21 /pmc/articles/PMC4439554/ /pubmed/26052283 http://dx.doi.org/10.3389/fnagi.2015.00087 Text en Copyright © 2015 Zamroziewicz, Paul, Rubin and Barbey. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution and reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Neuroscience Zamroziewicz, Marta K. Paul, Erick J. Rubin, Rachael D. Barbey, Aron K. Anterior cingulate cortex mediates the relationship between O3PUFAs and executive functions in APOE e4 carriers |
title | Anterior cingulate cortex mediates the relationship between O3PUFAs and executive functions in APOE e4 carriers |
title_full | Anterior cingulate cortex mediates the relationship between O3PUFAs and executive functions in APOE e4 carriers |
title_fullStr | Anterior cingulate cortex mediates the relationship between O3PUFAs and executive functions in APOE e4 carriers |
title_full_unstemmed | Anterior cingulate cortex mediates the relationship between O3PUFAs and executive functions in APOE e4 carriers |
title_short | Anterior cingulate cortex mediates the relationship between O3PUFAs and executive functions in APOE e4 carriers |
title_sort | anterior cingulate cortex mediates the relationship between o3pufas and executive functions in apoe e4 carriers |
topic | Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4439554/ https://www.ncbi.nlm.nih.gov/pubmed/26052283 http://dx.doi.org/10.3389/fnagi.2015.00087 |
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