A Mutant Allele Encoding DNA Binding–Deficient FoxO1 Differentially Regulates Hepatic Glucose and Lipid Metabolism

Insulin signaling in the liver blunts glucose production and stimulates triglyceride biosynthesis. FoxO1 is required for cAMP induction of hepatic glucose production and is permissive for the effect of insulin to suppress this process. Moreover, FoxO1 ablation increases lipogenesis. In this study, w...

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Detalles Bibliográficos
Autores principales: Cook, Joshua R., Matsumoto, Michihiro, Banks, Alexander S., Kitamura, Tadahiro, Tsuchiya, Kyoichiro, Accili, Domenico
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Diabetes Association 2015
Materias:
Metabolism
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4439558/
https://www.ncbi.nlm.nih.gov/pubmed/25576059
http://dx.doi.org/10.2337/db14-1506

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