Genetic variants in microRNA genes: impact on microRNA expression, function, and disease

MicroRNAs (miRNAs) are important regulators of gene expression and like any other gene, their coding sequences are subject to genetic variation. Variants in miRNA genes can have profound effects on miRNA functionality at all levels, including miRNA transcription, maturation, and target specificity,...

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Autores principales: Cammaerts, Sophia, Strazisar, Mojca, De Rijk, Peter, Del Favero, Jurgen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2015
Materias:
Genetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4439572/
https://www.ncbi.nlm.nih.gov/pubmed/26052338
http://dx.doi.org/10.3389/fgene.2015.00186
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author Cammaerts, Sophia
Strazisar, Mojca
De Rijk, Peter
Del Favero, Jurgen
author_facet Cammaerts, Sophia
Strazisar, Mojca
De Rijk, Peter
Del Favero, Jurgen
author_sort Cammaerts, Sophia
collection PubMed
description MicroRNAs (miRNAs) are important regulators of gene expression and like any other gene, their coding sequences are subject to genetic variation. Variants in miRNA genes can have profound effects on miRNA functionality at all levels, including miRNA transcription, maturation, and target specificity, and as such they can also contribute to disease. The impact of variants in miRNA genes is the focus of the present review. To put these effects into context, we first discuss the requirements of miRNA transcripts for maturation. In the last part an overview of available databases and tools and experimental approaches to investigate miRNA variants related to human disease is presented.
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spelling pubmed-44395722015-06-05 Genetic variants in microRNA genes: impact on microRNA expression, function, and disease Cammaerts, Sophia Strazisar, Mojca De Rijk, Peter Del Favero, Jurgen Front Genet Genetics MicroRNAs (miRNAs) are important regulators of gene expression and like any other gene, their coding sequences are subject to genetic variation. Variants in miRNA genes can have profound effects on miRNA functionality at all levels, including miRNA transcription, maturation, and target specificity, and as such they can also contribute to disease. The impact of variants in miRNA genes is the focus of the present review. To put these effects into context, we first discuss the requirements of miRNA transcripts for maturation. In the last part an overview of available databases and tools and experimental approaches to investigate miRNA variants related to human disease is presented. Frontiers Media S.A. 2015-05-21 /pmc/articles/PMC4439572/ /pubmed/26052338 http://dx.doi.org/10.3389/fgene.2015.00186 Text en Copyright © 2015 Cammaerts, Strazisar, De Rijk and Del Favero. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Genetics
Cammaerts, Sophia
Strazisar, Mojca
De Rijk, Peter
Del Favero, Jurgen
Genetic variants in microRNA genes: impact on microRNA expression, function, and disease
title Genetic variants in microRNA genes: impact on microRNA expression, function, and disease
title_full Genetic variants in microRNA genes: impact on microRNA expression, function, and disease
title_fullStr Genetic variants in microRNA genes: impact on microRNA expression, function, and disease
title_full_unstemmed Genetic variants in microRNA genes: impact on microRNA expression, function, and disease
title_short Genetic variants in microRNA genes: impact on microRNA expression, function, and disease
title_sort genetic variants in microrna genes: impact on microrna expression, function, and disease
topic Genetics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4439572/
https://www.ncbi.nlm.nih.gov/pubmed/26052338
http://dx.doi.org/10.3389/fgene.2015.00186
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