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DNA adducts-chemical addons

DNA adduct is a piece of DNA covalently bond to a chemical (safrole, benzopyrenediol epoxide, acetaldehyde). This process could be the start of a cancerous cell. When a chemical binds to DNA, it gets damaged resulting in abnormal replication. This could be the start of a mutation and without proper...

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Autores principales: Rajalakshmi, T. R., AravindhaBabu, N., Shanmugam, K. T., Masthan, K. M. K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4439668/
https://www.ncbi.nlm.nih.gov/pubmed/26015708
http://dx.doi.org/10.4103/0975-7406.155901
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author Rajalakshmi, T. R.
AravindhaBabu, N.
Shanmugam, K. T.
Masthan, K. M. K.
author_facet Rajalakshmi, T. R.
AravindhaBabu, N.
Shanmugam, K. T.
Masthan, K. M. K.
author_sort Rajalakshmi, T. R.
collection PubMed
description DNA adduct is a piece of DNA covalently bond to a chemical (safrole, benzopyrenediol epoxide, acetaldehyde). This process could be the start of a cancerous cell. When a chemical binds to DNA, it gets damaged resulting in abnormal replication. This could be the start of a mutation and without proper DNA repair, this can lead to cancer. It is this chemical that binds with the DNA is our prime area of concern. Instead of performing the whole body analysis for diagnosing cancer, this test could be carried out for early detection of cancer. When scanning tunneling microscope is used, the DNA results can be obtained earlier. DNA adducts in scientific experiments are used as biomarkers.
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spelling pubmed-44396682015-05-26 DNA adducts-chemical addons Rajalakshmi, T. R. AravindhaBabu, N. Shanmugam, K. T. Masthan, K. M. K. J Pharm Bioallied Sci Dental Science - Review Article DNA adduct is a piece of DNA covalently bond to a chemical (safrole, benzopyrenediol epoxide, acetaldehyde). This process could be the start of a cancerous cell. When a chemical binds to DNA, it gets damaged resulting in abnormal replication. This could be the start of a mutation and without proper DNA repair, this can lead to cancer. It is this chemical that binds with the DNA is our prime area of concern. Instead of performing the whole body analysis for diagnosing cancer, this test could be carried out for early detection of cancer. When scanning tunneling microscope is used, the DNA results can be obtained earlier. DNA adducts in scientific experiments are used as biomarkers. Medknow Publications & Media Pvt Ltd 2015-04 /pmc/articles/PMC4439668/ /pubmed/26015708 http://dx.doi.org/10.4103/0975-7406.155901 Text en Copyright: © Journal of Pharmacy and Bioallied Sciences http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Dental Science - Review Article
Rajalakshmi, T. R.
AravindhaBabu, N.
Shanmugam, K. T.
Masthan, K. M. K.
DNA adducts-chemical addons
title DNA adducts-chemical addons
title_full DNA adducts-chemical addons
title_fullStr DNA adducts-chemical addons
title_full_unstemmed DNA adducts-chemical addons
title_short DNA adducts-chemical addons
title_sort dna adducts-chemical addons
topic Dental Science - Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4439668/
https://www.ncbi.nlm.nih.gov/pubmed/26015708
http://dx.doi.org/10.4103/0975-7406.155901
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