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Ketamine coadministration attenuates morphine tolerance and leads to increased brain concentrations of both drugs in the rat
BACKGROUND AND PURPOSE: The effects of ketamine in attenuating morphine tolerance have been suggested to result from a pharmacodynamic interaction. We studied whether ketamine might increase brain morphine concentrations in acute coadministration, in morphine tolerance and morphine withdrawal. EXPER...
Autores principales: | Lilius, T O, Jokinen, V, Neuvonen, M S, Niemi, M, Kalso, E A, Rauhala, P V |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BlackWell Publishing Ltd
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4439876/ https://www.ncbi.nlm.nih.gov/pubmed/25297798 http://dx.doi.org/10.1111/bph.12974 |
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