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Ketamine coadministration attenuates morphine tolerance and leads to increased brain concentrations of both drugs in the rat

BACKGROUND AND PURPOSE: The effects of ketamine in attenuating morphine tolerance have been suggested to result from a pharmacodynamic interaction. We studied whether ketamine might increase brain morphine concentrations in acute coadministration, in morphine tolerance and morphine withdrawal. EXPER...

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Detalles Bibliográficos
Autores principales:	Lilius, T O, Jokinen, V, Neuvonen, M S, Niemi, M, Kalso, E A, Rauhala, P V
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BlackWell Publishing Ltd 2015
Materias:	Research Papers
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4439876/ https://www.ncbi.nlm.nih.gov/pubmed/25297798 http://dx.doi.org/10.1111/bph.12974

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