Short-term variability in QT interval and ventricular arrhythmias induced by dofetilide are dependent on high-frequency autonomic oscillations

BACKGROUND AND PURPOSE: The present study was undertaken to investigate an effect of dofetilide, a potent arrhythmic blocker of the voltage-gated K(+) channel, hERG, on cardiac autonomic control. Combined with effects on ardiomyocytes, these properties could influence its arrhythmic potency. EXPERIM...

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Detalles Bibliográficos
Autores principales: Champeroux, P, Thireau, J, Judé, S, Laigot-Barbé, C, Maurin, A, Sola, M L, Fowler, J S L, Richard, S, Le Guennec, J Y
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BlackWell Publishing Ltd 2015
Materias:
Research Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4439882/
https://www.ncbi.nlm.nih.gov/pubmed/25625756
http://dx.doi.org/10.1111/bph.13093

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