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Elastase and metalloproteinase-9 concentrations in saliva in patients with chronic periodontitis

Elastase and metalloproteinase-9 (MMP-9) are two of numerous proteolytic enzymes released by neutrophilic granulocytes in the course of periodontitis. The aim of the study was to determine the concentrations of elastase and MMP-9 in saliva in patients with chronic periodontitis compared to healthy i...

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Autores principales: Nędzi-Góra, Małgorzata, Kostrzewa-Janicka, Jolanta, Górska, Renata
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Polish Society of Experimental and Clinical Immunology 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4439995/
https://www.ncbi.nlm.nih.gov/pubmed/26155148
http://dx.doi.org/10.5114/ceji.2014.45948
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author Nędzi-Góra, Małgorzata
Kostrzewa-Janicka, Jolanta
Górska, Renata
author_facet Nędzi-Góra, Małgorzata
Kostrzewa-Janicka, Jolanta
Górska, Renata
author_sort Nędzi-Góra, Małgorzata
collection PubMed
description Elastase and metalloproteinase-9 (MMP-9) are two of numerous proteolytic enzymes released by neutrophilic granulocytes in the course of periodontitis. The aim of the study was to determine the concentrations of elastase and MMP-9 in saliva in patients with chronic periodontitis compared to healthy individuals. The enzyme-linked immunosorbent assay method was employed to determine the concentrations of elastase and MMP-9 in saliva in patients with chronic periodontitis and with pocket depth (PD) ≥ 6 mm and PD < 6 mm, as well as in saliva of healthy individuals. Significantly higher concentrations of elastase and MMP-9 were observed in patients with periodontitis compared to healthy individuals (p < 0.01). Also a significant difference in elastase concentration in saliva was observed between the PD ≥ 4 mm and PD < 6 mm groups and between the PD ≥ 6 mm and control groups, and statistically significant differences in MMP-9 concentrations between the PD ≥ 6 mm and control groups. No statistically significant differences were observed between the PD < 6 mm and control groups for elastase concentrations in saliva as well as between the PD ≥ 6 mm and PD < 6 mm groups, and also between the PD < 6 mm and control groups for MMP-9 concentrations in saliva. Elastase and MMP-9 concentrations in saliva can be considered as biochemical indicators of severity of periodontitis.
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spelling pubmed-44399952015-07-07 Elastase and metalloproteinase-9 concentrations in saliva in patients with chronic periodontitis Nędzi-Góra, Małgorzata Kostrzewa-Janicka, Jolanta Górska, Renata Cent Eur J Immunol Original Article Elastase and metalloproteinase-9 (MMP-9) are two of numerous proteolytic enzymes released by neutrophilic granulocytes in the course of periodontitis. The aim of the study was to determine the concentrations of elastase and MMP-9 in saliva in patients with chronic periodontitis compared to healthy individuals. The enzyme-linked immunosorbent assay method was employed to determine the concentrations of elastase and MMP-9 in saliva in patients with chronic periodontitis and with pocket depth (PD) ≥ 6 mm and PD < 6 mm, as well as in saliva of healthy individuals. Significantly higher concentrations of elastase and MMP-9 were observed in patients with periodontitis compared to healthy individuals (p < 0.01). Also a significant difference in elastase concentration in saliva was observed between the PD ≥ 4 mm and PD < 6 mm groups and between the PD ≥ 6 mm and control groups, and statistically significant differences in MMP-9 concentrations between the PD ≥ 6 mm and control groups. No statistically significant differences were observed between the PD < 6 mm and control groups for elastase concentrations in saliva as well as between the PD ≥ 6 mm and PD < 6 mm groups, and also between the PD < 6 mm and control groups for MMP-9 concentrations in saliva. Elastase and MMP-9 concentrations in saliva can be considered as biochemical indicators of severity of periodontitis. Polish Society of Experimental and Clinical Immunology 2014-10-14 2014 /pmc/articles/PMC4439995/ /pubmed/26155148 http://dx.doi.org/10.5114/ceji.2014.45948 Text en Copyright © Central European Journal of Immunology 2014 http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-Noncommercial 3.0 Unported License, permitting all non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Nędzi-Góra, Małgorzata
Kostrzewa-Janicka, Jolanta
Górska, Renata
Elastase and metalloproteinase-9 concentrations in saliva in patients with chronic periodontitis
title Elastase and metalloproteinase-9 concentrations in saliva in patients with chronic periodontitis
title_full Elastase and metalloproteinase-9 concentrations in saliva in patients with chronic periodontitis
title_fullStr Elastase and metalloproteinase-9 concentrations in saliva in patients with chronic periodontitis
title_full_unstemmed Elastase and metalloproteinase-9 concentrations in saliva in patients with chronic periodontitis
title_short Elastase and metalloproteinase-9 concentrations in saliva in patients with chronic periodontitis
title_sort elastase and metalloproteinase-9 concentrations in saliva in patients with chronic periodontitis
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4439995/
https://www.ncbi.nlm.nih.gov/pubmed/26155148
http://dx.doi.org/10.5114/ceji.2014.45948
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