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The effect of Zingiber officinale R. rhizomes (ginger) on plasma pro-inflammatory cytokine levels in well-trained male endurance runners
The aim of this study was to investigate the effect of ginger on the concentrations of plasma interleukin-1β (IL-1β), interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) in welltrained male endurance runners. To this end, twenty-eight high-level endurance runners were randomly assigned to two g...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Polish Society of Experimental and Clinical Immunology
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4440027/ https://www.ncbi.nlm.nih.gov/pubmed/26155120 http://dx.doi.org/10.5114/ceji.2014.43719 |
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author | Zehsaz, Farzad Farhangi, Negin Mirheidari, Lamia |
author_facet | Zehsaz, Farzad Farhangi, Negin Mirheidari, Lamia |
author_sort | Zehsaz, Farzad |
collection | PubMed |
description | The aim of this study was to investigate the effect of ginger on the concentrations of plasma interleukin-1β (IL-1β), interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) in welltrained male endurance runners. To this end, twenty-eight high-level endurance runners were randomly assigned to two groups (control and experimental). They performed the same weekly training volume for 12 weeks. The Bruce treadmill test was used three days before the start of the 12-week training period and after weeks 6 and 12 to evaluate the physiological effects of training and ginger administration. After completing the first 6-week period of exercise training protocol, two groups received 500 mg capsules of ginger powder and placebo, respectively, three times a day for the second 6-week period. Blood samples were collected before (resting blood sample) and after the Bruce treadmill test. IL-1β, IL-6 and TNF-α were assayed using standard commercial ELISA kits. Two-way repeated measures analysis of variance (ANOVA) was used to determine significant differences between control and experimental plasma IL-6, IL-1β and TNF-α concentration means of pre- and post-test periods. The IL-1β, IL-6 and TNF-α concentrations at the end of week 12/weeks 6 and 12 between two training groups were significantly different (p = 0.01, p = 0.01, and p = 0.01). In the experimental group alone, there were also significant differences in the mean IL-1β, IL-6 and TNF-α concentrations at the end of weeks 6 and 12 (p = 0.01, p = 0.01, and p = 0.01). Our findings indicated that post-exercise plasma elevations of several pro-inflammatory cytokines can be attenuated by a six-week ginger administration period. |
format | Online Article Text |
id | pubmed-4440027 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Polish Society of Experimental and Clinical Immunology |
record_format | MEDLINE/PubMed |
spelling | pubmed-44400272015-07-07 The effect of Zingiber officinale R. rhizomes (ginger) on plasma pro-inflammatory cytokine levels in well-trained male endurance runners Zehsaz, Farzad Farhangi, Negin Mirheidari, Lamia Cent Eur J Immunol Original Article The aim of this study was to investigate the effect of ginger on the concentrations of plasma interleukin-1β (IL-1β), interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) in welltrained male endurance runners. To this end, twenty-eight high-level endurance runners were randomly assigned to two groups (control and experimental). They performed the same weekly training volume for 12 weeks. The Bruce treadmill test was used three days before the start of the 12-week training period and after weeks 6 and 12 to evaluate the physiological effects of training and ginger administration. After completing the first 6-week period of exercise training protocol, two groups received 500 mg capsules of ginger powder and placebo, respectively, three times a day for the second 6-week period. Blood samples were collected before (resting blood sample) and after the Bruce treadmill test. IL-1β, IL-6 and TNF-α were assayed using standard commercial ELISA kits. Two-way repeated measures analysis of variance (ANOVA) was used to determine significant differences between control and experimental plasma IL-6, IL-1β and TNF-α concentration means of pre- and post-test periods. The IL-1β, IL-6 and TNF-α concentrations at the end of week 12/weeks 6 and 12 between two training groups were significantly different (p = 0.01, p = 0.01, and p = 0.01). In the experimental group alone, there were also significant differences in the mean IL-1β, IL-6 and TNF-α concentrations at the end of weeks 6 and 12 (p = 0.01, p = 0.01, and p = 0.01). Our findings indicated that post-exercise plasma elevations of several pro-inflammatory cytokines can be attenuated by a six-week ginger administration period. Polish Society of Experimental and Clinical Immunology 2014-06-27 2014 /pmc/articles/PMC4440027/ /pubmed/26155120 http://dx.doi.org/10.5114/ceji.2014.43719 Text en Copyright © Central European Journal of Immunology 2014 http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-Noncommercial 3.0 Unported License, permitting all non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Zehsaz, Farzad Farhangi, Negin Mirheidari, Lamia The effect of Zingiber officinale R. rhizomes (ginger) on plasma pro-inflammatory cytokine levels in well-trained male endurance runners |
title | The effect of Zingiber officinale R. rhizomes (ginger) on plasma pro-inflammatory cytokine levels in well-trained male endurance runners |
title_full | The effect of Zingiber officinale R. rhizomes (ginger) on plasma pro-inflammatory cytokine levels in well-trained male endurance runners |
title_fullStr | The effect of Zingiber officinale R. rhizomes (ginger) on plasma pro-inflammatory cytokine levels in well-trained male endurance runners |
title_full_unstemmed | The effect of Zingiber officinale R. rhizomes (ginger) on plasma pro-inflammatory cytokine levels in well-trained male endurance runners |
title_short | The effect of Zingiber officinale R. rhizomes (ginger) on plasma pro-inflammatory cytokine levels in well-trained male endurance runners |
title_sort | effect of zingiber officinale r. rhizomes (ginger) on plasma pro-inflammatory cytokine levels in well-trained male endurance runners |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4440027/ https://www.ncbi.nlm.nih.gov/pubmed/26155120 http://dx.doi.org/10.5114/ceji.2014.43719 |
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