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Behavioral Disturbances in Estrogen-Related Receptor alpha-Null Mice

Eating disorders, such as anorexia nervosa and bulimia nervosa, are common and severe mental illnesses of unknown etiology. Recently, we identified a rare missense mutation in the transcription factor estrogen-related receptor alpha (ESRRA) that is associated with the development of eating disorders...

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Autores principales: Cui, Huxing, Lu, Yuan, Khan, Michael Z., Anderson, Rachel M., McDaniel, Latisha, Wilson, Hannah E., Yin, Terry C., Radley, Jason J., Pieper, Andrew A., Lutter, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4440329/
https://www.ncbi.nlm.nih.gov/pubmed/25865889
http://dx.doi.org/10.1016/j.celrep.2015.03.032
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author Cui, Huxing
Lu, Yuan
Khan, Michael Z.
Anderson, Rachel M.
McDaniel, Latisha
Wilson, Hannah E.
Yin, Terry C.
Radley, Jason J.
Pieper, Andrew A.
Lutter, Michael
author_facet Cui, Huxing
Lu, Yuan
Khan, Michael Z.
Anderson, Rachel M.
McDaniel, Latisha
Wilson, Hannah E.
Yin, Terry C.
Radley, Jason J.
Pieper, Andrew A.
Lutter, Michael
author_sort Cui, Huxing
collection PubMed
description Eating disorders, such as anorexia nervosa and bulimia nervosa, are common and severe mental illnesses of unknown etiology. Recently, we identified a rare missense mutation in the transcription factor estrogen-related receptor alpha (ESRRA) that is associated with the development of eating disorders. However, little is known about ESRRA function in the brain. Here, we report that Esrra is expressed in the mouse brain and demonstrate that Esrra levels are regulated by energy reserves. Esrra-null female mice display a reduced operant response to a high-fat diet, compulsivity/behavioral rigidity, and social deficits. Selective Esrra knockdown in the prefrontal and orbitofrontal cortices of adult female mice recapitulates reduced operant response and increased compulsivity, respectively. These results indicate that Esrra deficiency in the mouse brain impairs behavioral responses in multiple functional domains.
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spelling pubmed-44403292016-04-21 Behavioral Disturbances in Estrogen-Related Receptor alpha-Null Mice Cui, Huxing Lu, Yuan Khan, Michael Z. Anderson, Rachel M. McDaniel, Latisha Wilson, Hannah E. Yin, Terry C. Radley, Jason J. Pieper, Andrew A. Lutter, Michael Cell Rep Article Eating disorders, such as anorexia nervosa and bulimia nervosa, are common and severe mental illnesses of unknown etiology. Recently, we identified a rare missense mutation in the transcription factor estrogen-related receptor alpha (ESRRA) that is associated with the development of eating disorders. However, little is known about ESRRA function in the brain. Here, we report that Esrra is expressed in the mouse brain and demonstrate that Esrra levels are regulated by energy reserves. Esrra-null female mice display a reduced operant response to a high-fat diet, compulsivity/behavioral rigidity, and social deficits. Selective Esrra knockdown in the prefrontal and orbitofrontal cortices of adult female mice recapitulates reduced operant response and increased compulsivity, respectively. These results indicate that Esrra deficiency in the mouse brain impairs behavioral responses in multiple functional domains. 2015-04-09 2015-04-21 /pmc/articles/PMC4440329/ /pubmed/25865889 http://dx.doi.org/10.1016/j.celrep.2015.03.032 Text en ©2015 The Authors This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Article
Cui, Huxing
Lu, Yuan
Khan, Michael Z.
Anderson, Rachel M.
McDaniel, Latisha
Wilson, Hannah E.
Yin, Terry C.
Radley, Jason J.
Pieper, Andrew A.
Lutter, Michael
Behavioral Disturbances in Estrogen-Related Receptor alpha-Null Mice
title Behavioral Disturbances in Estrogen-Related Receptor alpha-Null Mice
title_full Behavioral Disturbances in Estrogen-Related Receptor alpha-Null Mice
title_fullStr Behavioral Disturbances in Estrogen-Related Receptor alpha-Null Mice
title_full_unstemmed Behavioral Disturbances in Estrogen-Related Receptor alpha-Null Mice
title_short Behavioral Disturbances in Estrogen-Related Receptor alpha-Null Mice
title_sort behavioral disturbances in estrogen-related receptor alpha-null mice
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4440329/
https://www.ncbi.nlm.nih.gov/pubmed/25865889
http://dx.doi.org/10.1016/j.celrep.2015.03.032
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