Clinical Impact of the Immunome in Lymphoid Malignancies: The Role of Myeloid-Derived Suppressor Cells

The better definition of the mutual sustainment between neoplastic cells and immune system has been translated from the bench to the bedside acquiring value as prognostic factor. Additionally, it represents a promising tool for improving therapeutic strategies. In this context, myeloid-derived suppr...

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Detalles Bibliográficos
Autores principales: Vetro, Calogero, Romano, Alessandra, Ancora, Flavia, Coppolino, Francesco, Brundo, Maria V., Raccuia, Salvatore A., Puglisi, Fabrizio, Tibullo, Daniele, La Cava, Piera, Giallongo, Cesarina, Parrinello, Nunziatina L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2015
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4440379/
https://www.ncbi.nlm.nih.gov/pubmed/26052505
http://dx.doi.org/10.3389/fonc.2015.00104
Descripción
Sumario:The better definition of the mutual sustainment between neoplastic cells and immune system has been translated from the bench to the bedside acquiring value as prognostic factor. Additionally, it represents a promising tool for improving therapeutic strategies. In this context, myeloid-derived suppressor cells (MDSCs) have gained a central role in tumor developing with consequent therapeutic implications. In this review, we will focus on the biological and clinical impact of the study of MDSCs in the settings of lymphoid malignancies.

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