Intra-tumor genetic heterogeneity and alternative driver genetic alterations in breast cancers with heterogeneous HER2 gene amplification

BACKGROUND: HER2 is overexpressed and amplified in approximately 15% of invasive breast cancers, and is the molecular target and predictive marker of response to anti-HER2 agents. In a subset of these cases, heterogeneous distribution of HER2 gene amplification can be found, which creates clinically...

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Detalles Bibliográficos
Autores principales: Ng, Charlotte KY, Martelotto, Luciano G, Gauthier, Arnaud, Wen, Huei-Chi, Piscuoglio, Salvatore, Lim, Raymond S, Cowell, Catherine F, Wilkerson, Paul M, Wai, Patty, Rodrigues, Daniel N, Arnould, Laurent, Geyer, Felipe C, Bromberg, Silvio E, Lacroix-Triki, Magali, Penault-Llorca, Frederique, Giard, Sylvia, Sastre-Garau, Xavier, Natrajan, Rachael, Norton, Larry, Cottu, Paul H, Weigelt, Britta, Vincent-Salomon, Anne, Reis-Filho, Jorge S
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4440518/
https://www.ncbi.nlm.nih.gov/pubmed/25994018
http://dx.doi.org/10.1186/s13059-015-0657-6

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