JBP485 promotes tear and mucin secretion in ocular surface epithelia

Dry eye syndrome (DES), a multifactorial disease of the tears and ocular surface, is one of the most common ocular disorders. Tear film contains ocular mucins and is essential for maintaining the homeostasis of the wet ocular surface. Since there are a limited number of clinical options for the trea...

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Autores principales: Nakamura, Takahiro, Hata, Yuiko, Nagata, Maho, Yokoi, Norihiko, Yamaguchi, Shumpei, Kaku, Taiichi, Kinoshita, Shigeru
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4440520/
https://www.ncbi.nlm.nih.gov/pubmed/25996902
http://dx.doi.org/10.1038/srep10248
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author Nakamura, Takahiro
Hata, Yuiko
Nagata, Maho
Yokoi, Norihiko
Yamaguchi, Shumpei
Kaku, Taiichi
Kinoshita, Shigeru
author_facet Nakamura, Takahiro
Hata, Yuiko
Nagata, Maho
Yokoi, Norihiko
Yamaguchi, Shumpei
Kaku, Taiichi
Kinoshita, Shigeru
author_sort Nakamura, Takahiro
collection PubMed
description Dry eye syndrome (DES), a multifactorial disease of the tears and ocular surface, is one of the most common ocular disorders. Tear film contains ocular mucins and is essential for maintaining the homeostasis of the wet ocular surface. Since there are a limited number of clinical options for the treatment of DES, additional novel treatments are needed to improve the clinical results. In this study, we found that placental extract-derived dipeptide (JBP485) clearly promoted the expression and secretion of gel-forming mucin 5ac (Muc5ac) in rabbit conjunctival epithelium. JBP485 also elevated the expression level of cell surface-associated mucins (Muc1/4/16) in rabbit corneal epithelium. The Schirmer tear test results indicated that JBP485 induced tear secretion in the rabbit model. Moreover, JBP485 clinically improved corneal epithelial damage in a mouse dry eye model. Thus, our data indicate that JBP485 efficiently promoted mucin and aqueous tear secretion in rabbit ocular surface epithelium and has the potential to be used as a novel treatment for DES.
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spelling pubmed-44405202015-05-29 JBP485 promotes tear and mucin secretion in ocular surface epithelia Nakamura, Takahiro Hata, Yuiko Nagata, Maho Yokoi, Norihiko Yamaguchi, Shumpei Kaku, Taiichi Kinoshita, Shigeru Sci Rep Article Dry eye syndrome (DES), a multifactorial disease of the tears and ocular surface, is one of the most common ocular disorders. Tear film contains ocular mucins and is essential for maintaining the homeostasis of the wet ocular surface. Since there are a limited number of clinical options for the treatment of DES, additional novel treatments are needed to improve the clinical results. In this study, we found that placental extract-derived dipeptide (JBP485) clearly promoted the expression and secretion of gel-forming mucin 5ac (Muc5ac) in rabbit conjunctival epithelium. JBP485 also elevated the expression level of cell surface-associated mucins (Muc1/4/16) in rabbit corneal epithelium. The Schirmer tear test results indicated that JBP485 induced tear secretion in the rabbit model. Moreover, JBP485 clinically improved corneal epithelial damage in a mouse dry eye model. Thus, our data indicate that JBP485 efficiently promoted mucin and aqueous tear secretion in rabbit ocular surface epithelium and has the potential to be used as a novel treatment for DES. Nature Publishing Group 2015-05-21 /pmc/articles/PMC4440520/ /pubmed/25996902 http://dx.doi.org/10.1038/srep10248 Text en Copyright © 2015, Macmillan Publishers Limited http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
spellingShingle Article
Nakamura, Takahiro
Hata, Yuiko
Nagata, Maho
Yokoi, Norihiko
Yamaguchi, Shumpei
Kaku, Taiichi
Kinoshita, Shigeru
JBP485 promotes tear and mucin secretion in ocular surface epithelia
title JBP485 promotes tear and mucin secretion in ocular surface epithelia
title_full JBP485 promotes tear and mucin secretion in ocular surface epithelia
title_fullStr JBP485 promotes tear and mucin secretion in ocular surface epithelia
title_full_unstemmed JBP485 promotes tear and mucin secretion in ocular surface epithelia
title_short JBP485 promotes tear and mucin secretion in ocular surface epithelia
title_sort jbp485 promotes tear and mucin secretion in ocular surface epithelia
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4440520/
https://www.ncbi.nlm.nih.gov/pubmed/25996902
http://dx.doi.org/10.1038/srep10248
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