The Expression of Functional Vpx during Pathogenic SIVmac Infections of Rhesus Macaques Suppresses SAMHD1 in CD4(+) Memory T Cells

For nearly 20 years, the principal biological function of the HIV-2/SIV Vpx gene has been thought to be required for optimal virus replication in myeloid cells. Mechanistically, this Vpx activity was recently reported to involve the degradation of Sterile Alpha Motif and HD domain-containing protein...

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Detalles Bibliográficos
Autores principales: Shingai, Masashi, Welbourn, Sarah, Brenchley, Jason M., Acharya, Priyamvada, Miyagi, Eri, Plishka, Ronald J., Buckler-White, Alicia, Kwong, Peter D., Nishimura, Yoshiaki, Strebel, Klaus, Martin, Malcolm A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4440783/
https://www.ncbi.nlm.nih.gov/pubmed/25996507
http://dx.doi.org/10.1371/journal.ppat.1004928

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