Cargando…

Positron Emission Tomography studies with [(11)C]PBR28 in the Healthy Rodent Brain: Validating SUV as an Outcome Measure of Neuroinflammation

Molecular imaging of the 18 kD Translocator protein (TSPO) with positron emission tomography (PET) is of great value for studying neuroinflammation in rodents longitudinally. Quantification of the TSPO in rodents is, however, quite challenging. There is no suitable reference region and the use of pl...

Descripción completa

Detalles Bibliográficos
Autores principales:	Tóth, Miklós, Doorduin, Janine, Häggkvist, Jenny, Varrone, Andrea, Amini, Nahid, Halldin, Christer, Gulyás, Balázs
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4440816/ https://www.ncbi.nlm.nih.gov/pubmed/25996996 http://dx.doi.org/10.1371/journal.pone.0125917

Ejemplares similares

ABC transporter-dependent brain uptake of the 5-HT(1B) receptor radioligand [(11)C]AZ10419369: a comparative PET study in mouse, rat, and guinea pig
por: Tóth, Miklós, et al.
Publicado: (2014)

Astrocytosis precedes amyloid plaque deposition in Alzheimer APPswe transgenic mouse brain: a correlative positron emission tomography and in vitro imaging study
por: Rodriguez-Vieitez, Elena, et al.
Publicado: (2015)

PET imaging of [(11)C]PBR28 in Parkinson’s disease patients does not indicate increased binding to TSPO despite reduced dopamine transporter binding
por: Varnäs, Katarina, et al.
Publicado: (2018)

An In Vivo Study of a Rat Fluid-Percussion-Induced Traumatic Brain Injury Model with [(11)C]PBR28 and [(18)F]flumazenil PET Imaging
por: Ghosh, Krishna Kanta, et al.
Publicado: (2021)

Neuroinflammation in frontotemporal lobar degeneration revealed by (11)C‐PBR28 PET
por: Kim, Min-Jeong, et al.
Publicado: (2019)

Serotonin 1B receptor density mapping of the human brainstem using positron emission tomography and autoradiography
por: Veldman, Emma R, et al.
Publicado: (2021)

Microsome Mediated in Vitro Metabolism: A Convenient Method for the Preparation of the PET Radioligand Metabolite [(18)F]FE-PE2I-OH for Translational Dopamine Transporter Imaging
por: Schou, Magnus, et al.
Publicado: (2023)

Assessment of simplified ratio-based approaches for quantification of PET [(11)C]PBR28 data
por: Matheson, Granville J., et al.
Publicado: (2017)

PET imaging of microglia using PBR28suv determines therapeutic efficacy of autologous bone marrow mononuclear cells therapy in traumatic brain injury
por: Bedi, Supinder S., et al.
Publicado: (2023)

A pilot [(11)C]PBR28 PET/MRI study of neuroinflammation and neurodegeneration in chronic stroke patients
por: Schaechter, Judith D., et al.
Publicado: (2021)

PET Imaging of VMAT2 with the Novel Radioligand [(18)F]FE-DTBZ-d4 in Nonhuman Primates: Comparison with [(11)C]DTBZ and [(18)F]FE-DTBZ
por: Nag, Sangram, et al.
Publicado: (2021)

Influence of alcoholism and cholesterol on TSPO binding in brain: PET [(11)C]PBR28 studies in humans and rodents
por: Kim, Sung Won, et al.
Publicado: (2018)

Improved Automated Radiosynthesis of [(11)C]PBR28
por: Solingapuram Sai, Kiran Kumar, et al.
Publicado: (2015)

Association of neuroinflammation with episodic memory: a [(11)C]PBR28 PET study in cognitively discordant twin pairs
por: Lindgren, Noora, et al.
Publicado: (2020)

Association of Early β-Amyloid Accumulation and Neuroinflammation Measured With [(11)C]PBR28 in Elderly Individuals Without Dementia
por: Toppala, Sini, et al.
Publicado: (2021)

Evaluating [(11)C]PBR28 PET for Monitoring Gut and Brain Inflammation in a Rat Model of Chemically Induced Colitis
por: Kurtys, E., et al.
Publicado: (2016)

Parametric mapping using spectral analysis for (11)C-PBR28 PET reveals neuroinflammation in mild cognitive impairment subjects
por: Fan, Zhen, et al.
Publicado: (2018)

Effects of age, BMI and sex on the glial cell marker TSPO — a multicentre [(11)C]PBR28 HRRT PET study
por: Tuisku, Jouni, et al.
Publicado: (2019)

Evaluation of exercise-induced modulation of glial activation and dopaminergic damage in a rat model of Parkinson’s disease using [(11)C]PBR28 and [(18)F]FDOPA PET
por: Real, Caroline C, et al.
Publicado: (2017)

Neuroinflammation in post-acute sequelae of COVID-19 (PASC) as assessed by [(11)C]PBR28 PET correlates with vascular disease measures
por: VanElzakker, Michael B., et al.
Publicado: (2023)

[(11)C]MADAM Used as a Model for Understanding the Radiometabolism of Diphenyl Sulfide Radioligands for Positron Emission Tomography (PET)
por: Gourand, Fabienne, et al.
Publicado: (2015)

Positron emission tomography and functional characterization of a complete PBR/TSPO knockout
por: Banati, Richard B., et al.
Publicado: (2014)

Guidelines to PET measurements of the target occupancy in the brain for drug development
por: Takano, Akihiro, et al.
Publicado: (2016)

Quantification of [(11)C]PBR28 data after systemic lipopolysaccharide challenge
por: Woodcock, Eric A., et al.
Publicado: (2020)

A dual tracer [(11)C]PBR28 and [(18)F]FDG microPET evaluation of neuroinflammation and brain energy metabolism in murine endotoxemia
por: Palandira, Santhoshi P., et al.
Publicado: (2022)

Microglial depletion and activation: A [(11)C]PBR28 PET study in nonhuman primates
por: Hillmer, Ansel T., et al.
Publicado: (2017)

Increased in vivo glial activation in patients with amyotrophic lateral sclerosis: Assessed with [(11)C]-PBR28
por: Zürcher, Nicole R., et al.
Publicado: (2015)

Auxin inhibits lignin and cellulose biosynthesis in stone cells of pear fruit via the PbrARF13‐PbrNSC‐PbrMYB132 transcriptional regulatory cascade
por: Xu, Shaozhuo, et al.
Publicado: (2023)

Direct Comparison of [(18)F]F-DPA with [(18)F]DPA-714 and [(11)C]PBR28 for Neuroinflammation Imaging in the same Alzheimer’s Disease Model Mice and Healthy Controls
por: López-Picón, Francisco R., et al.
Publicado: (2021)

Serotonin and Norepinephrine Transporter Occupancy of Tramadol in Nonhuman Primate Using Positron Emission Tomography
por: Arakawa, Ryosuke, et al.
Publicado: (2018)

Revisiting the Logan plot to account for non-negligible blood volume in brain tissue
por: Schain, Martin, et al.
Publicado: (2017)

PbrRALF2-elicited reactive oxygen species signaling is mediated by the PbrCrRLK1L13-PbrMPK18 module in pear pollen tubes
por: Kou, Xiaobing, et al.
Publicado: (2021)

[(18)F]PBR146 and [(18)F]DPA-714 in vivo Imaging of Neuroinflammation in Chronic Hepatic Encephalopathy Rats
por: Kong, Xiang, et al.
Publicado: (2021)

Dealing with PET radiometabolites
por: Ghosh, Krishna Kanta, et al.
Publicado: (2020)

Is cyclooxygenase‐1 involved in neuroinflammation?
por: Ghazanfari, Nafiseh, et al.
Publicado: (2021)

An 18-kDa Translocator Protein (TSPO) polymorphism explains differences in binding affinity of the PET radioligand PBR28
por: Owen, David R, et al.
Publicado: (2012)

Utility of (18) F-FDG and (11)C-PBR28 microPET for the assessment of rat aortic aneurysm inflammation
por: English, Sean J, et al.
Publicado: (2014)

Test-retest analysis of a non-invasive method of quantifying [(11)C]-PBR28 binding in Alzheimer’s disease
por: Nair, Akshay, et al.
Publicado: (2016)

Synthesis and Characterization of a “Clickable” PBR28 TSPO-Selective Ligand Derivative Suitable for the Functionalization of Biodegradable Polymer Nanoparticles
por: Auriemma, Renato, et al.
Publicado: (2021)

Differential Effect of APOE Alleles on Brain Glucose Metabolism in Targeted Replacement Mice: An [(18)F]FDG-μPET Study
por: Venzi, Marcello, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_dkshhb6vtor4mhgtm9694o0rg3