Cargando…
DA-Raf-Mediated Suppression of the Ras—ERK Pathway Is Essential for TGF-β1-Induced Epithelial—Mesenchymal Transition in Alveolar Epithelial Type 2 Cells
Myofibroblasts play critical roles in the development of idiopathic pulmonary fibrosis by depositing components of extracellular matrix. One source of lung myofibroblasts is thought to be alveolar epithelial type 2 cells that undergo epithelial–mesenchymal transition (EMT). Rat RLE-6TN alveolar epit...
Autores principales: | Watanabe-Takano, Haruko, Takano, Kazunori, Hatano, Masahiko, Tokuhisa, Takeshi, Endo, Takeshi |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2015
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4440819/ https://www.ncbi.nlm.nih.gov/pubmed/25996975 http://dx.doi.org/10.1371/journal.pone.0127888 |
Ejemplares similares
-
DA-Raf1, a competent intrinsic dominant-negative antagonist of the Ras–ERK pathway, is required for myogenic differentiation
por: Yokoyama, Takashi, et al.
Publicado: (2007) -
Transcriptional repression of p27 is essential for murine embryonic development
por: Teratake, Youichi, et al.
Publicado: (2016) -
Classical RAS proteins are not essential for paradoxical ERK activation induced by RAF inhibitors
por: Lai, Lick Pui, et al.
Publicado: (2022) -
Kinetics and protective role of autophagy in a mouse cecal ligation and puncture-induced sepsis
por: Takahashi, Waka, et al.
Publicado: (2013) -
Exposure to mold proteases stimulates mucin production in airway epithelial cells through Ras/Raf1/ERK signal pathway
por: Wu, Xianxian, et al.
Publicado: (2020)