Broad-spectrum antiviral agents

Development of highly effective, broad-spectrum antiviral agents is the major objective shared by the fields of virology and pharmaceutics. Antiviral drug development has focused on targeting viral entry and replication, as well as modulating cellular defense system. High throughput screening of mol...

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Detalles Bibliográficos
Autores principales: Zhu, Jun-Da, Meng, Wen, Wang, Xiao-Jia, Wang, Hwa-Chain R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2015
Materias:
Microbiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4440912/
https://www.ncbi.nlm.nih.gov/pubmed/26052325
http://dx.doi.org/10.3389/fmicb.2015.00517
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author Zhu, Jun-Da
Meng, Wen
Wang, Xiao-Jia
Wang, Hwa-Chain R.
author_facet Zhu, Jun-Da
Meng, Wen
Wang, Xiao-Jia
Wang, Hwa-Chain R.
author_sort Zhu, Jun-Da
collection PubMed
description Development of highly effective, broad-spectrum antiviral agents is the major objective shared by the fields of virology and pharmaceutics. Antiviral drug development has focused on targeting viral entry and replication, as well as modulating cellular defense system. High throughput screening of molecules, genetic engineering of peptides, and functional screening of agents have identified promising candidates for development of optimal broad-spectrum antiviral agents to intervene in viral infection and control viral epidemics. This review discusses current knowledge, prospective applications, opportunities, and challenges in the development of broad-spectrum antiviral agents.
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spelling pubmed-44409122015-06-05 Broad-spectrum antiviral agents Zhu, Jun-Da Meng, Wen Wang, Xiao-Jia Wang, Hwa-Chain R. Front Microbiol Microbiology Development of highly effective, broad-spectrum antiviral agents is the major objective shared by the fields of virology and pharmaceutics. Antiviral drug development has focused on targeting viral entry and replication, as well as modulating cellular defense system. High throughput screening of molecules, genetic engineering of peptides, and functional screening of agents have identified promising candidates for development of optimal broad-spectrum antiviral agents to intervene in viral infection and control viral epidemics. This review discusses current knowledge, prospective applications, opportunities, and challenges in the development of broad-spectrum antiviral agents. Frontiers Media S.A. 2015-05-22 /pmc/articles/PMC4440912/ /pubmed/26052325 http://dx.doi.org/10.3389/fmicb.2015.00517 Text en Copyright © 2015 Zhu, Meng, Wang and Wang. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Microbiology
Zhu, Jun-Da
Meng, Wen
Wang, Xiao-Jia
Wang, Hwa-Chain R.
Broad-spectrum antiviral agents
title Broad-spectrum antiviral agents
title_full Broad-spectrum antiviral agents
title_fullStr Broad-spectrum antiviral agents
title_full_unstemmed Broad-spectrum antiviral agents
title_short Broad-spectrum antiviral agents
title_sort broad-spectrum antiviral agents
topic Microbiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4440912/
https://www.ncbi.nlm.nih.gov/pubmed/26052325
http://dx.doi.org/10.3389/fmicb.2015.00517
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