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High-titer foamy virus vector transduction and integration sites of human CD34(+) cell–derived SCID-repopulating cells
Foamy virus (FV) vectors are promising tools for gene therapy, but low titer is a major challenge for large-scale clinical trials. Here, we increased FV vector titer 50-fold by constructing novel vector plasmids and using polyethylenimine-mediated transfection. FV and lentiviral (LV) vectors were us...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group
2014
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4441046/ https://www.ncbi.nlm.nih.gov/pubmed/26015964 http://dx.doi.org/10.1038/mtm.2014.20 |