Hypoxia drives transient site-specific copy gain and drug-resistant gene expression

Copy number heterogeneity is a prominent feature within tumors. The molecular basis for this heterogeneity remains poorly characterized. Here, we demonstrate that hypoxia induces transient site-specific copy gains (TSSGs) in primary, nontransformed, and transformed human cells. Hypoxia-driven copy g...

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Detalles Bibliográficos
Autores principales: Black, Joshua C., Atabakhsh, Elnaz, Kim, Jaegil, Biette, Kelly M., Van Rechem, Capucine, Ladd, Brendon, Burrowes, Paul d., Donado, Carlos, Mattoo, Hamid, Kleinstiver, Benjamin P., Song, Bing, Andriani, Grasiella, Joung, J. Keith, Iliopoulos, Othon, Montagna, Cristina, Pillai, Shiv, Getz, Gad, Whetstine, Johnathan R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2015
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4441050/
https://www.ncbi.nlm.nih.gov/pubmed/25995187
http://dx.doi.org/10.1101/gad.259796.115

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