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piRNA-directed cleavage of meiotic transcripts regulates spermatogenesis

MIWI catalytic activity is required for spermatogenesis, indicating that piRNA-guided cleavage is critical for germ cell development. To identify meiotic piRNA targets, we augmented the mouse piRNA repertoire by introducing a human meiotic piRNA cluster. This triggered a spermatogenesis defect by in...

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Detalles Bibliográficos
Autores principales:	Goh, Wee Siong Sho, Falciatori, Ilaria, Tam, Oliver H., Burgess, Ralph, Meikar, Oliver, Kotaja, Noora, Hammell, Molly, Hannon, Gregory J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cold Spring Harbor Laboratory Press 2015
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4441051/ https://www.ncbi.nlm.nih.gov/pubmed/25995188 http://dx.doi.org/10.1101/gad.260455.115

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