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Position-specific binding of FUS to nascent RNA regulates mRNA length

More than half of all human genes produce prematurely terminated polyadenylated short mRNAs. However, the underlying mechanisms remain largely elusive. CLIP-seq (cross-linking immunoprecipitation [CLIP] combined with deep sequencing) of FUS (fused in sarcoma) in neuronal cells showed that FUS is fre...

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Detalles Bibliográficos
Autores principales: Masuda, Akio, Takeda, Jun-ichi, Okuno, Tatsuya, Okamoto, Takaaki, Ohkawara, Bisei, Ito, Mikako, Ishigaki, Shinsuke, Sobue, Gen, Ohno, Kinji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4441052/
https://www.ncbi.nlm.nih.gov/pubmed/25995189
http://dx.doi.org/10.1101/gad.255737.114