Cargando…

Position-specific binding of FUS to nascent RNA regulates mRNA length

More than half of all human genes produce prematurely terminated polyadenylated short mRNAs. However, the underlying mechanisms remain largely elusive. CLIP-seq (cross-linking immunoprecipitation [CLIP] combined with deep sequencing) of FUS (fused in sarcoma) in neuronal cells showed that FUS is fre...

Descripción completa

Detalles Bibliográficos
Autores principales:	Masuda, Akio, Takeda, Jun-ichi, Okuno, Tatsuya, Okamoto, Takaaki, Ohkawara, Bisei, Ito, Mikako, Ishigaki, Shinsuke, Sobue, Gen, Ohno, Kinji
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cold Spring Harbor Laboratory Press 2015
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4441052/ https://www.ncbi.nlm.nih.gov/pubmed/25995189 http://dx.doi.org/10.1101/gad.255737.114

Ejemplares similares

Position-dependent FUS-RNA interactions regulate alternative splicing events and transcriptions
por: Ishigaki, Shinsuke, et al.
Publicado: (2012)

ERRATUM: Position-dependent FUS-RNA interactions regulate alternative splicing events and transcriptions
por: Ishigaki, Shinsuke, et al.
Publicado: (2013)

The ALS/FTLD-related RNA-binding proteins TDP-43 and FUS have common downstream RNA targets in cortical neurons()
por: Honda, Daiyu, et al.
Publicado: (2013)

R-spondin 2 promotes acetylcholine receptor clustering at the neuromuscular junction via Lgr5
por: Nakashima, Hiroaki, et al.
Publicado: (2016)

Corrigendum to “The ALS/FTLD-related RNA-binding proteins TDP-43 and FUS have common downstream RNA targets in cortical neurons” [FEBS Open Bio 4 (2014) 1–10]
por: Honda, Daiyu, et al.
Publicado: (2014)

Lansoprazole Upregulates Polyubiquitination of the TNF Receptor-Associated Factor 6 and Facilitates Runx2-mediated Osteoblastogenesis
por: Mishima, Kenichi, et al.
Publicado: (2015)

SRSF1 suppresses selection of intron-distal 5′ splice site of DOK7 intron 4 to generate functional full-length Dok-7 protein
por: Ahsan, Khalid Bin, et al.
Publicado: (2017)

FUS-regulated region- and cell-type-specific transcriptome is associated with cell selectivity in ALS/FTLD
por: Fujioka, Yusuke, et al.
Publicado: (2013)

Differential effects of spinal motor neuron-derived and skeletal muscle-derived Rspo2 on acetylcholine receptor clustering at the neuromuscular junction
por: Li, Jin, et al.
Publicado: (2018)

ERRATUM: FUS-regulated region- and cell-type-specific transcriptome is associated with cell selectivity in ALS/FTLD
por: Fujioka, Yusuke, et al.
Publicado: (2013)

Neural Isoforms of Agrin Are Generated by Reduced PTBP1−RNA Interaction Network Spanning the Neuron−Specific Splicing Regions in AGRN
por: Bushra, Samira, et al.
Publicado: (2023)

Gene Expression Profile at the Motor Endplate of the Neuromuscular Junction of Fast-Twitch Muscle
por: Huang, Kun, et al.
Publicado: (2020)

Secreted Signaling Molecules at the Neuromuscular Junction in Physiology and Pathology
por: Ohkawara, Bisei, et al.
Publicado: (2021)

Phenylbutazone induces expression of MBNL1 and suppresses formation of MBNL1-CUG RNA foci in a mouse model of myotonic dystrophy
por: Chen, Guiying, et al.
Publicado: (2016)

Importance of Functional Loss of FUS in FTLD/ALS
por: Ishigaki, Shinsuke, et al.
Publicado: (2018)

Verapamil Protects against Cartilage Degradation in Osteoarthritis by Inhibiting Wnt/β-Catenin Signaling
por: Takamatsu, Akira, et al.
Publicado: (2014)

Competitive regulation of alternative splicing and alternative polyadenylation by hnRNP H and CstF64 determines acetylcholinesterase isoforms
por: Nazim, Mohammad, et al.
Publicado: (2017)

Mianserin suppresses R-spondin 2-induced activation of Wnt/β-catenin signaling in chondrocytes and prevents cartilage degradation in a rat model of osteoarthritis
por: Okura, Toshiaki, et al.
Publicado: (2019)

Author Correction: Mianserin suppresses R-spondin 2-induced activation of Wnt/β-catenin signaling in chondrocytes and prevents cartilage degradation in a rat model of osteoarthritis
por: Okura, Toshiaki, et al.
Publicado: (2020)

Molecular hydrogen suppresses activated Wnt/β-catenin signaling
por: Lin, Yingni, et al.
Publicado: (2016)

Meclozine Facilitates Proliferation and Differentiation of Chondrocytes by Attenuating Abnormally Activated FGFR3 Signaling in Achondroplasia
por: Matsushita, Masaki, et al.
Publicado: (2013)

Wnt/β-catenin signaling suppresses expressions of Scx, Mkx, and Tnmd in tendon-derived cells
por: Kishimoto, Yasuzumi, et al.
Publicado: (2017)

Fluoxetine ameliorates cartilage degradation in osteoarthritis by inhibiting Wnt/β-catenin signaling
por: Miyamoto, Kentaro, et al.
Publicado: (2017)

Inhibition of cyclooxygenase-1 by nonsteroidal anti-inflammatory drugs demethylates MeR2 enhancer and promotes Mbnl1 transcription in myogenic cells
por: Huang, Kun, et al.
Publicado: (2020)

Repositioning again of zonisamide for nerve regeneration
por: Ohno, Kinji, et al.
Publicado: (2016)

FUS regulates AMPA receptor function and FTLD/ALS-associated behaviour via GluA1 mRNA stabilization
por: Udagawa, Tsuyoshi, et al.
Publicado: (2015)

Splicing regulation of GFPT1 muscle-specific isoform and its roles in glucose metabolisms and neuromuscular junction
por: Farshadyeganeh, Paniz, et al.
Publicado: (2023)

CUGBP1 and MBNL1 preferentially bind to 3′ UTRs and facilitate mRNA decay
por: Masuda, Akio, et al.
Publicado: (2012)

Collagen Q and anti-MuSK autoantibody competitively suppress agrin/LRP4/MuSK signaling
por: Otsuka, Kenji, et al.
Publicado: (2015)

Zonisamide ameliorates progression of cervical spondylotic myelopathy in a rat model
por: Kanbara, Shunsuke, et al.
Publicado: (2020)

Widespread binding of FUS along nascent RNA regulates alternative splicing in the brain
por: Rogelj, Boris, et al.
Publicado: (2012)

Rapidly Growing Protein-Centric Technologies to Extensively Identify Protein–RNA Interactions: Application to the Analysis of Co-Transcriptional RNA Processing
por: Masuda, Akio, et al.
Publicado: (2021)

Clinical and Pathologic Features of Congenital Myasthenic Syndromes Caused by 35 Genes—A Comprehensive Review
por: Ohno, Kinji, et al.
Publicado: (2023)

Correction: Zonisamide Enhances Neurite Elongation of Primary Motor Neurons and Facilitates Peripheral Nerve Regeneration In Vitro and in a Mouse Model
por: Yagi, Hideki, et al.
Publicado: (2016)

Zonisamide Enhances Neurite Elongation of Primary Motor Neurons and Facilitates Peripheral Nerve Regeneration In Vitro and in a Mouse Model
por: Yagi, Hideki, et al.
Publicado: (2015)

Lack of Fgf18 causes abnormal clustering of motor nerve terminals at the neuromuscular junction with reduced acetylcholine receptor clusters
por: Ito, Kenyu, et al.
Publicado: (2018)

Extremely low-frequency pulses of faint magnetic field induce mitophagy to rejuvenate mitochondria
por: Toda, Takuro, et al.
Publicado: (2022)

RNA sequence and length contribute to RNA-induced conformational change of TLS/FUS
por: Hamad, Nesreen, et al.
Publicado: (2020)

A mutation in DOK7 in congenital myasthenic syndrome forms aggresome in cultured cells, and reduces DOK7 expression and MuSK phosphorylation in patient-derived iPS cells
por: Zhang, Shaochuan, et al.
Publicado: (2022)

Meclozine ameliorates bone mineralization and growth plate structure in a mouse model of X‑linked hypophosphatemia
por: Kamiya, Yasunari, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_sk1fl7pe6pi2qtrktig93atff8