LIN28 cooperates with WNT signaling to drive invasive intestinal and colorectal adenocarcinoma in mice and humans

Colorectal cancer (CRC) remains a major contributor to cancer-related mortality. LIN28A and LIN28B are highly related RNA-binding protein paralogs that regulate biogenesis of let-7 microRNAs and influence development, metabolism, tissue regeneration, and oncogenesis. Here we demonstrate that overexp...

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Detalles Bibliográficos
Autores principales: Tu, Ho-Chou, Schwitalla, Sarah, Qian, Zhirong, LaPier, Grace S., Yermalovich, Alena, Ku, Yuan-Chieh, Chen, Shann-Ching, Viswanathan, Srinivas R., Zhu, Hao, Nishihara, Reiko, Inamura, Kentaro, Kim, Sun A., Morikawa, Teppei, Mima, Kosuke, Sukawa, Yasutaka, Yang, Juhong, Meredith, Gavin, Fuchs, Charles S., Ogino, Shuji, Daley, George Q.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2015
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4441054/
https://www.ncbi.nlm.nih.gov/pubmed/25956904
http://dx.doi.org/10.1101/gad.256693.114

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