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Synergistic Effect of S224P and N383D Substitutions in the PA of H5N1 Avian Influenza Virus Contributes to Mammalian Adaptation

The adaptation of H5N1 avian influenza viruses to human poses a great threat to public health. Previous studies indicate the adaptive mutations in viral polymerase of avian influenza viruses are major contributors in overcoming the host species barrier, with the majority of mammalian adaptive mutati...

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Detalles Bibliográficos
Autores principales:	Song, Jiasheng, Xu, Jing, Shi, Jianzhong, Li, Yanbing, Chen, Hualan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2015
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4441148/ https://www.ncbi.nlm.nih.gov/pubmed/26000865 http://dx.doi.org/10.1038/srep10510

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