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Telling true from false: cannabis users show increased susceptibility to false memories
Previous studies on the neurocognitive impact of cannabis use have found working and declarative memory deficits that tend to normalize with abstinence. An unexplored aspect of cognitive function in chronic cannabis users is the ability to distinguish between veridical and illusory memories, a cruci...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4441258/ https://www.ncbi.nlm.nih.gov/pubmed/25824306 http://dx.doi.org/10.1038/mp.2015.36 |
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author | Riba, J Valle, M Sampedro, F Rodríguez-Pujadas, A Martínez-Horta, S Kulisevsky, J Rodríguez-Fornells, A |
author_facet | Riba, J Valle, M Sampedro, F Rodríguez-Pujadas, A Martínez-Horta, S Kulisevsky, J Rodríguez-Fornells, A |
author_sort | Riba, J |
collection | PubMed |
description | Previous studies on the neurocognitive impact of cannabis use have found working and declarative memory deficits that tend to normalize with abstinence. An unexplored aspect of cognitive function in chronic cannabis users is the ability to distinguish between veridical and illusory memories, a crucial aspect of reality monitoring that relies on adequate memory function and cognitive control. Using functional magnetic resonance imaging, we show that abstinent cannabis users have an increased susceptibility to false memories, failing to identify lure stimuli as events that never occurred. In addition to impaired performance, cannabis users display reduced activation in areas associated with memory processing within the lateral and medial temporal lobe (MTL), and in parietal and frontal brain regions involved in attention and performance monitoring. Furthermore, cannabis consumption was inversely correlated with MTL activity, suggesting that the drug is especially detrimental to the episodic aspects of memory. These findings indicate that cannabis users have an increased susceptibility to memory distortions even when abstinent and drug-free, suggesting a long-lasting compromise of memory and cognitive control mechanisms involved in reality monitoring. |
format | Online Article Text |
id | pubmed-4441258 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Nature Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-44412582015-06-09 Telling true from false: cannabis users show increased susceptibility to false memories Riba, J Valle, M Sampedro, F Rodríguez-Pujadas, A Martínez-Horta, S Kulisevsky, J Rodríguez-Fornells, A Mol Psychiatry Original Article Previous studies on the neurocognitive impact of cannabis use have found working and declarative memory deficits that tend to normalize with abstinence. An unexplored aspect of cognitive function in chronic cannabis users is the ability to distinguish between veridical and illusory memories, a crucial aspect of reality monitoring that relies on adequate memory function and cognitive control. Using functional magnetic resonance imaging, we show that abstinent cannabis users have an increased susceptibility to false memories, failing to identify lure stimuli as events that never occurred. In addition to impaired performance, cannabis users display reduced activation in areas associated with memory processing within the lateral and medial temporal lobe (MTL), and in parietal and frontal brain regions involved in attention and performance monitoring. Furthermore, cannabis consumption was inversely correlated with MTL activity, suggesting that the drug is especially detrimental to the episodic aspects of memory. These findings indicate that cannabis users have an increased susceptibility to memory distortions even when abstinent and drug-free, suggesting a long-lasting compromise of memory and cognitive control mechanisms involved in reality monitoring. Nature Publishing Group 2015-06 2015-03-31 /pmc/articles/PMC4441258/ /pubmed/25824306 http://dx.doi.org/10.1038/mp.2015.36 Text en Copyright © 2015 Macmillan Publishers Limited http://creativecommons.org/licenses/by-nc-nd/4.0/ This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/4.0/ |
spellingShingle | Original Article Riba, J Valle, M Sampedro, F Rodríguez-Pujadas, A Martínez-Horta, S Kulisevsky, J Rodríguez-Fornells, A Telling true from false: cannabis users show increased susceptibility to false memories |
title | Telling true from false: cannabis users show increased susceptibility to false memories |
title_full | Telling true from false: cannabis users show increased susceptibility to false memories |
title_fullStr | Telling true from false: cannabis users show increased susceptibility to false memories |
title_full_unstemmed | Telling true from false: cannabis users show increased susceptibility to false memories |
title_short | Telling true from false: cannabis users show increased susceptibility to false memories |
title_sort | telling true from false: cannabis users show increased susceptibility to false memories |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4441258/ https://www.ncbi.nlm.nih.gov/pubmed/25824306 http://dx.doi.org/10.1038/mp.2015.36 |
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